Protein Classes
Protein Summary
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
- ENST00000518498
- ENSP00000430690
- ENSG00000160180
- ITF
- TFI
- ITF
- P1B
- TFI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.96 | ||
gene perturbation | 0.91 | ||
biological term | 0.8 | ||
kinase perturbation | 0.66 | ||
small molecule perturbation | 0.6 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 859.2 (req: < 5)
Gene RIFs: 113 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 859.2 (req: >= 5)
Gene RIFs: 113 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (6)
Reactome (4)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ESR-mediated signaling | ||||
Reactome | Estrogen-dependent gene expression | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Nuclear Receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ESR-mediated signaling | ||||
Estrogen-dependent gene expression | ||||
Signal Transduction | ||||
Signaling by Nuclear Receptors | ||||
Gene Ontology Terms (5)
Components (3)
Processes (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (70)
1 – 10 of 70
ERBB2
Family: Kinase
Novelty: 0.00003761
Score: 0.965
Data Source: STRINGDB
EGFR
Family: Kinase
Novelty: 0.00007274
Score: 0.959
Data Source: STRINGDB
TFF1
Novelty: 0.00295014
Score: 0.944
Data Source: STRINGDB
FOXA1
Family: TF
Novelty: 0.00235269
Score: 0.943
Data Source: STRINGDB
ESR1
Family: NR
Novelty: 0.00005938
Score: 0.936
Data Source: STRINGDB
GATA3
Family: TF
Novelty: 0.00071141
Score: 0.93
Data Source: STRINGDB
CTNNB1
Novelty: 0.0000744
Score: 0.925
Data Source: STRINGDB
TFF2
Novelty: 0.00346693
Score: 0.916
Data Source: STRINGDB
EP300
Family: Epigenetic
Novelty: 0.00055009
Score: 0.905
Data Source: STRINGDB
GH1
Novelty: 0.00072523
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score 859.20
PubMed score by year
PubTator Score 350.75
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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