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Tclin
PDE4B
cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329654
  • ENSP00000332116
  • ENSG00000184588
  • ENST00000341517
  • ENSP00000342637
  • ENST00000371045
  • ENSP00000360084
  • ENST00000423207
  • ENSP00000392947
  • ENST00000480109
  • ENSP00000432592

Symbol
  • DPDE4
  • DPDE4
  • PDEIVB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.95
drug
0.92
molecular function
0.91
PubMedID
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.05   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.05   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 880
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
7
7
98
smoking status measurement
2
2
3
97.2
alcohol consumption measurement
5
4
5
93.2
mathematical ability
2
3
3
92.8
body mass index
2
2
2
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
7
98
smoking status measurement
3
97.2
alcohol consumption measurement
5
93.2
mathematical ability
3
92.8
body mass index
2
90.2
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 4B
VGNC:8089
456921
Macaque
phosphodiesterase 4B
699309
Mouse
MGI:99557
18578
Rat
RGD:3280
24626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 4B
Macaque
phosphodiesterase 4B
Mouse
Rat
Protein Structure (43 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q07343-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 43
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
DARPP-32 events (R-HSA-180024)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DARPP-32 events
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Opioid Signalling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
DARPP-32 events
G alpha (i) signalling events
GPCR downstream signalling
Opioid Signalling
Signal Transduction
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (153)
1 – 10 of 153
PDE4D
Tclin
Family: Enzyme
Novelty: 0.00339482
p_int: 0.999999595
p_wrong: 4.05e-7
Score: 0.856
Data Source: BioPlex,STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.965
Data Source: Reactome,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
Score: 0.95
Data Source: Reactome,STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.943
Data Source: Reactome,STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.922
Data Source: STRINGDB
PPP1R1B
Tbio
Family: Enzyme
Novelty: 0.00152848
Score: 0.918
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.906
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.904
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.903
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  182.05

PubMed score by year
PubTator Score  127.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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