You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PIGF
Phosphatidylinositol-glycan biosynthesis class F protein

Protein Summary
Description
Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI. This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281382
  • ENSP00000281382
  • ENSG00000151665
  • ENST00000306465
  • ENSP00000302663
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.96
histone modification site profile
0.92
metabolite
0.73
co-expressed gene
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.59   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.59   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
PIGO
Tbio
Family:  Enzyme
Novelty:  0.05949164
Score:  0.978
Data Source:  Reactome,STRINGDB
PIGG
Tbio
Family:  Enzyme
Novelty:  0.01573185
Score:  0.966
Data Source:  Reactome,STRINGDB
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
Score:  0.961
Data Source:  STRINGDB
GPAA1
Tbio
Novelty:  0.01874575
Score:  0.957
Data Source:  STRINGDB
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
Score:  0.94
Data Source:  STRINGDB
PIGS
Tdark
Family:  Enzyme
Novelty:  0.36443235
Score:  0.909
Data Source:  STRINGDB
PIGK
Tbio
Family:  Enzyme
Novelty:  0.02333499
Score:  0.909
Data Source:  STRINGDB
PIGU
Tbio
Novelty:  0.11800036
Score:  0.904
Data Source:  STRINGDB
PIGA
Tbio
Family:  Enzyme
Novelty:  0.00172769
Score:  0.856
Data Source:  STRINGDB
PIGN
Tbio
Family:  Enzyme
Novelty:  0.02210783
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
1
1
17.8
body height
1
1
1
13.3
parental genotype effect measurement
1
1
1
6.8
birth weight
1
1
1
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
17.8
body height
1
13.3
parental genotype effect measurement
1
6.8
birth weight
1
6.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class F
VGNC:1941
459207
Macaque
phosphatidylinositol glycan anchor biosynthesis class F
714844
Mouse
MGI:99462
18701
Rat
RGD:1584658
681086
Dog
phosphatidylinositol glycan anchor biosynthesis class F
VGNC:44532
474580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class F
Macaque
phosphatidylinositol glycan anchor biosynthesis class F
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class F
Publication Statistics
PubMed Score 0.59
PubMed score by year
PubTator Score 87.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title