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Tbio
CXCL9
C-X-C motif chemokine 9

Protein Summary
Description
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3. This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264888
  • ENSP00000354901
  • ENSG00000138755

Symbol
  • CMK
  • MIG
  • SCYB9
  • CMK
  • MIG
  • Humig
  • SCYB9
  • crg-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
biological term
0.86
virus perturbation
0.85
disease
0.64
tissue sample
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1390.98   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 564   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1390.98   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
2
2
0
1.7
91.4
fetal genotype effect measurement
1
1
1
61.4
protein measurement
1
1
1
61.4
monokine induced by gamma interferon measurement
1
2
2
57.7
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
0
1.7
91.4
fetal genotype effect measurement
1
61.4
protein measurement
1
61.4
monokine induced by gamma interferon measurement
2
57.7
1
24.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 9
VGNC:8666
471200
Mouse
MGI:1352449
17329
Rat
RGD:628798
246759
Horse
C-X-C motif chemokine ligand 9
VGNC:16985
100057927
Cow
C-X-C motif chemokine ligand 9
VGNC:27854
513990
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 9
Mouse
Rat
Horse
C-X-C motif chemokine ligand 9
Cow
C-X-C motif chemokine ligand 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q07325-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (27)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (404)
1 – 10 of 404
CXCR3
Tchem
Family:  GPCR
Novelty:  0.00100538
Score:  0.996
Data Source:  Reactome,STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.991
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.988
Data Source:  STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.985
Data Source:  STRINGDB
CCL19
Tbio
Novelty:  0.00169711
Score:  0.984
Data Source:  STRINGDB
PF4
Tbio
Novelty:  0.00038481
Score:  0.983
Data Source:  STRINGDB
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.983
Data Source:  STRINGDB
CXCL11
Tbio
Novelty:  0.00077765
Score:  0.981
Data Source:  STRINGDB
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.979
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.977
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1390.98

PubMed score by year
PubTator Score  474.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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