Tbio TJP1 Tight junction protein ZO-1

Protein Summary

Description

TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• Q07157
• B4E3K1
• Q2NKP3
• Q4ZGJ6

Gene Name

• TJP1

Ensembl ID

• ENST00000346128
• ENSP00000281537
• ENSG00000104067
• ENST00000545208
• ENSP00000441202
• ENST00000621049
• ENSP00000484535
• ENSG00000277401

Symbol

• ZO1
• ZO-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	1
protein domain	0.99
virus perturbation	0.99
hub protein	0.96
chemical	0.94

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Tight Junction Protein Zo-1

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Tight Junction Protein Zo-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2414.01   (req: < 5)

Gene RIFs: 140   (req: <= 3)

Antibodies: 387   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2414.01   (req: >= 5)

Gene RIFs: 140   (req: > 3)

Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (332)

Explore Interacting Targets

1 – 10 of 332

• See Interactions on String-DB

MAGIX

Tdark

Novelty:  0.38577176

p_int:  0.999999755

p_ni:  2.42e-7

p_wrong:  3e-9

Score:  0.227

Data Source:  BioPlex,STRINGDB

SOWAHB

Tdark

Novelty:  1.09724527

p_int:  0.99999884

p_ni:  0.00000116

Data Source:  BioPlex

IFI30

Tbio

Family:  Enzyme

Novelty:  0.00939681

p_int:  0.999978054

p_ni:  0.000021946

Data Source:  BioPlex

CCDC102B

Tdark

Novelty:  0.28075569

p_int:  0.999721211

p_ni:  0.000278788

p_wrong:  1e-9

Data Source:  BioPlex

RNF166

Tdark

Novelty:  0.71460884

p_int:  0.996541691

p_ni:  0.003458304

p_wrong:  4e-9

Data Source:  BioPlex

KBTBD7

Tdark

Novelty:  0.4947466

p_int:  0.995278397

p_ni:  0.004721603

Score:  0.17

Data Source:  BioPlex,STRINGDB

CGN

Tbio

Novelty:  0.01097394

p_int:  0.989483293

p_ni:  0.010516695

p_wrong:  1.2e-8

Score:  0.935

Data Source:  BioPlex,STRINGDB

DEFA1

Tbio

Novelty:  0.01027492

p_int:  0.986512647

p_ni:  0.013487319

p_wrong:  3.4e-8

Data Source:  BioPlex

CRYBA4

Tbio

Novelty:  0.03692663

p_int:  0.949196867

p_ni:  0.050803131

p_wrong:  1e-9

Score:  0.167

Data Source:  BioPlex,STRINGDB

IL17F

Tbio

Novelty:  0.00223549

p_int:  0.881261805

p_ni:  0.118730264

p_wrong:  0.000007932

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (34)

Reactome (16)

KEGG (6)

PathwayCommons (2)

WikiPathways (10)

Apoptosis (R-HSA-109581)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic cleavage of cell adhesion proteins	11 targets	R-HSA-351906
Reactome	Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Reactome	Apoptotic execution phase	52 targets	R-HSA-75153
Reactome	Gap junction trafficking and regulation	30 targets	R-HSA-157858

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Apoptotic cleavage of cell adhesion proteins	11 targets	R-HSA-351906
Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Apoptotic execution phase	52 targets	R-HSA-75153
Gap junction trafficking and regulation	30 targets	R-HSA-157858

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (2)

Components (12)

Processes (5)

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1 – 2 of 2

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	3	3	0	3.9	87.6
corneal topography	EFO_0004345	1	1	1		48.5
heel bone mineral density	EFO_0009270	1	1	1		38.2
body weights and measures	EFO_0004324	1	1	1		17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	0	3.9	87.6
corneal topography	EFO_0004345	1		48.5
heel bone mineral density	EFO_0009270	1		38.2
body weights and measures	EFO_0004324	1		17.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calmodulin-binding
Cell junction
Cell membrane
Cell projection
Complete proteome
Gap junction
Membrane
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
body weights and measures
central corneal thickness
corneal topography
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tight junction protein 1	VGNC:13429	453253
Mouse	tight junction protein 1	MGI:98759	21872
Rat	tight junction protein 1	RGD:1306305	292994
Dog	tight junction protein 1	VGNC:47386	403752
Horse	tight junction protein 1	VGNC:24118	100050412

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tight junction protein 1
Mouse	tight junction protein 1
Rat	tight junction protein 1
Dog	tight junction protein 1
Horse	tight junction protein 1

Publication Statistics

PubMed Score 2414.01

PubMed score by year

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PubTator Score 848.66

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Related Publications

Text Mined References (214)

GeneRif Annotations (140)

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PMID	Year	Title