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Tbio
TJP1
Tight junction protein ZO-1

Protein Summary
Description
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346128
  • ENSP00000281537
  • ENSG00000104067
  • ENST00000545208
  • ENSP00000441202
  • ENST00000621049
  • ENSP00000484535
  • ENSG00000277401

Symbol
  • ZO1
  • ZO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
protein domain
0.99
virus perturbation
0.99
hub protein
0.96
chemical
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2414.01   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2414.01   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
3
3
0
3.9
87.6
corneal topography
1
1
1
48.5
heel bone mineral density
1
1
1
38.2
body weights and measures
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3.9
87.6
corneal topography
1
48.5
heel bone mineral density
1
38.2
body weights and measures
1
17.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tight junction protein 1
VGNC:13429
453253
Mouse
MGI:98759
21872
Rat
RGD:1306305
292994
Dog
tight junction protein 1
VGNC:47386
403752
Horse
tight junction protein 1
VGNC:24118
100050412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tight junction protein 1
Mouse
Rat
Dog
tight junction protein 1
Horse
tight junction protein 1
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q07157-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Gap junction trafficking and regulation
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Gap junction trafficking and regulation
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (332)
1 – 10 of 332
MAGIX
Tdark
Novelty:  0.38577176
p_int:  0.999999755
p_ni:  2.42e-7
p_wrong:  3e-9
Score:  0.227
Data Source:  BioPlex,STRINGDB
SOWAHB
Tdark
Novelty:  1.09724527
p_int:  0.99999884
p_ni:  0.00000116
Data Source:  BioPlex
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.999978054
p_ni:  0.000021946
Data Source:  BioPlex
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.999721211
p_ni:  0.000278788
p_wrong:  1e-9
Data Source:  BioPlex
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.996541691
p_ni:  0.003458304
p_wrong:  4e-9
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.995278397
p_ni:  0.004721603
Score:  0.17
Data Source:  BioPlex,STRINGDB
CGN
Tbio
Novelty:  0.01097394
p_int:  0.989483293
p_ni:  0.010516695
p_wrong:  1.2e-8
Score:  0.935
Data Source:  BioPlex,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.986512647
p_ni:  0.013487319
p_wrong:  3.4e-8
Data Source:  BioPlex
CRYBA4
Tbio
Novelty:  0.03692663
p_int:  0.949196867
p_ni:  0.050803131
p_wrong:  1e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
IL17F
Tbio
Novelty:  0.00223549
p_int:  0.881261805
p_ni:  0.118730264
p_wrong:  0.000007932
Data Source:  BioPlex
Publication Statistics
PubMed Score  2414.01

PubMed score by year
PubTator Score  848.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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