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Tchem
CD69
Early activation antigen CD69

Protein Summary
Description
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228434
  • ENSP00000228434
  • ENSG00000110848

Symbol
  • CLEC2C
  • AIM
  • EA1
  • MLR-3
  • CLEC2C
  • GP32/28
  • BL-AC/P26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
virus perturbation
0.97
gene perturbation
0.9
biological term
0.65
chemical
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1477.81   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 1130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1477.81   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 1130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
6
7
95.3
myeloid white cell count
1
1
1
81.6
lymphocyte percentage of leukocytes
2
4
5
75
monocyte count
1
3
3
68.7
neutrophil percentage of leukocytes
2
3
3
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
7
95.3
myeloid white cell count
1
81.6
lymphocyte percentage of leukocytes
5
75
monocyte count
3
68.7
neutrophil percentage of leukocytes
3
66.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD69 molecule
VGNC:5331
465280
Macaque
CD69 molecule
717288
Mouse
MGI:88343
12515
Rat
RGD:61318
29187
Dog
CD69 molecule
VGNC:38968
477698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD69 molecule
Macaque
CD69 molecule
Mouse
Rat
Dog
CD69 molecule
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q07108-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (320)
Items per page:
1 – 5 of 320
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
IL-3 Signaling Pathway
WikiPathways
IL-3 Signaling Pathway
WikiPathways
IL-3 Signaling Pathway
WikiPathways
IL-3 Signaling Pathway
WikiPathways
IL-3 Signaling Pathway
Name
Explore in Pharos
Explore in Source
IL-3 Signaling Pathway
IL-3 Signaling Pathway
IL-3 Signaling Pathway
IL-3 Signaling Pathway
IL-3 Signaling Pathway
Protein-Protein Interactions (275)
1 – 10 of 275
PALM3
Tbio
Novelty: 0.07224273
p_int: 0.994366232
p_ni: 0.001668978
p_wrong: 0.003964789
Score: 0.416
Data Source: BioPlex,STRINGDB
ERICH5
Tdark
Novelty: 5.57504212
p_int: 0.971571632
p_ni: 0.028415707
p_wrong: 0.000012661
Score: 0.189
Data Source: BioPlex,STRINGDB
PYGB
Tbio
Family: Enzyme
Novelty: 0.00224148
p_int: 0.942227204
p_ni: 0.057772795
p_wrong: 1e-9
Score: 0.241
Data Source: BioPlex,STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
p_int: 0.846830815
p_ni: 0.153167822
p_wrong: 0.000001363
Score: 0.188
Data Source: BioPlex,STRINGDB
CADM4
Tbio
Novelty: 0.05034541
p_int: 0.791109841
p_ni: 0.000067039
p_wrong: 0.20882312
Score: 0.416
Data Source: BioPlex,STRINGDB
S1PR1
Tclin
Family: GPCR
Novelty: 0.00162513
Score: 0.962
Data Source: STRINGDB
CD28
Tbio
Novelty: 0.00036482
Score: 0.918
Data Source: STRINGDB
IL2
Tchem
Novelty: 0.00003129
Score: 0.912
Data Source: STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
Score: 0.909
Data Source: STRINGDB
SELL
Tchem
Novelty: 0.00030025
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  1477.81

PubMed score by year
PubTator Score  833.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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