Tchem ENPEP Glutamyl aminopeptidase

Protein Summary

Description

Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

Uniprot Accession IDs

• Q07075
• Q504U2
• EAP

Gene Name

• ENPEP

Ensembl ID

• ENST00000265162
• ENSP00000265162
• ENSG00000138792

Symbol

• APA
• CD249
• gp160

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
gene perturbation	0.76
cellular component	0.71
kinase perturbation	0.71
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Glutamyl Aminopeptidase

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Glutamyl Aminopeptidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 966.3   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 456   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 966.3   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0