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Tchem
ENPEP
Glutamyl aminopeptidase

Protein Summary
Description
Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265162
  • ENSP00000265162
  • ENSG00000138792

Symbol
  • APA
  • CD249
  • gp160
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
gene perturbation
0.76
cellular component
0.71
kinase perturbation
0.71
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 833.03   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 833.03   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
69.2
Calcium channel blocker use measurement
1
2
2
37.7
Agents acting on the renin-angiotensin system use measurement
1
2
2
34.7
diastolic blood pressure
1
1
1
19.1
1
1
1
11.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
69.2
Calcium channel blocker use measurement
2
37.7
Agents acting on the renin-angiotensin system use measurement
2
34.7
diastolic blood pressure
1
19.1
1
11.8
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (76)
1 – 10 of 76
FRMD5
Tbio
Novelty: 0.34991399
p_int: 0.981933089
p_ni: 0.008895821
p_wrong: 0.00917109
Score: 0.407
Data Source: BioPlex,STRINGDB
BNIP3
Tbio
Novelty: 0.00216392
p_int: 0.947875827
p_ni: 0.015232335
p_wrong: 0.036891838
Score: 0.37
Data Source: BioPlex,STRINGDB
AGT
Tbio
Novelty: 0.00049613
Score: 0.971
Data Source: Reactome,STRINGDB
ITIH4
Tbio
Novelty: 0.00032471
Score: 0.915
Data Source: STRINGDB
RPL22
Tbio
Novelty: 0.00473197
Score: 0.767
Data Source: STRINGDB
DNPEP
Tchem
Family: Enzyme
Novelty: 0.02415651
Score: 0.76
Data Source: STRINGDB
GPR160
Tbio
Family: GPCR
Novelty: 0.15856538
Score: 0.758
Data Source: STRINGDB
REN
Tclin
Family: Enzyme
Novelty: 0.00002435
Score: 0.682
Data Source: STRINGDB
ACE2
Tchem
Family: Enzyme
Novelty: 0.00028408
Score: 0.676
Data Source: STRINGDB
CRYGD
Tbio
Novelty: 0.00246109
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  833.03

PubMed score by year
PubTator Score  786.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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