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Tbio
CKAP4
Cytoskeleton-associated protein 4

Protein Summary
Description
High-affinity epithelial cell surface receptor for APF. Mediates the anchoring of the endoplasmic reticulum to microtubules.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378026
  • ENSP00000367265
  • ENSG00000136026

Symbol
  • p63
  • CLIMP-63
  • ERGIC-63
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.95
transcription factor perturbation
0.94
ligand (protein) perturbation
0.83
cellular component
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.43   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.43   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (326)
PRELP
Tbio
Novelty:  0.02849334
p_int:  0.999415611
p_ni:  0.000584389
Score:  0.179
Data Source:  BioPlex,STRINGDB
SEMA7A
Tbio
Novelty:  0.00741605
p_int:  0.998588278
p_ni:  0.001411722
Data Source:  BioPlex
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.998075308
p_ni:  0.001924692
Data Source:  BioPlex
B3GAT3
Tbio
Family:  Enzyme
Novelty:  0.0289834
p_int:  0.994818867
p_ni:  0.005181133
Score:  0.278
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.987505098
p_ni:  0.012494902
Data Source:  BioPlex
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.978285265
p_ni:  0.021714735
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.974207882
p_ni:  0.025792118
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.967476186
p_ni:  0.032523814
Data Source:  BioPlex
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.963534778
p_ni:  0.036465222
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.94578393
p_ni:  0.05421607
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroimaging measurement
11
1
11
80.1
lateral ventricle volume measurement
1
1
0
7.3
79.1
brain measurement
1
1
0
34.5
78.7
brain volume measurement
7
1
7
78.1
thalamus volume
1
1
1
77.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroimaging measurement
11
80.1
lateral ventricle volume measurement
0
7.3
79.1
brain measurement
0
34.5
78.7
brain volume measurement
7
78.1
thalamus volume
1
77.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytoskeleton associated protein 4
VGNC:12889
742720
Macaque
cytoskeleton associated protein 4
702779
Mouse
MGI:2444926
216197
Dog
cytoskeleton associated protein 4
VGNC:39288
481295
Horse
cytoskeleton associated protein 4 [Source:HGNC Symbol;Acc:HGNC:16991]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytoskeleton associated protein 4
Macaque
cytoskeleton associated protein 4
Mouse
Dog
cytoskeleton associated protein 4
Horse
cytoskeleton associated protein 4 [Source:HGNC Symbol;Acc:HGNC:16991]
Publication Statistics
PubMed Score 76.43
PubMed score by year
PubTator Score 38.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title