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Tbio
C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

Protein Summary
Description
Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling whi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225698
  • ENSP00000225698
  • ENSG00000108561

Symbol
  • GC1QBP
  • HABP1
  • SF2P32
  • p32
  • HABP1
  • gC1qR
  • GC1QBP
  • SF2p32
  • gC1Q-R
  • COXPD33
  • SF2AP32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
1
kinase perturbation
1
hub protein
0.99
disease perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.81   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.81   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (242)
1 – 10 of 242
BHLHA15
Tbio
Family: TF
Novelty: 0.02721846
p_int: 0.999643068
p_ni: 0.000356932
Data Source: BioPlex
CHCHD10
Tbio
Novelty: 0.01659548
p_int: 0.999631953
p_ni: 0.000368047
Score: 0.499
Data Source: BioPlex,STRINGDB
LUC7L
Tbio
Novelty: 0.05748021
p_int: 0.999377402
p_ni: 0.000622598
Data Source: BioPlex
MAGEB10
Tdark
Novelty: 2.96156972
p_int: 0.999003094
p_ni: 0.000996906
Data Source: BioPlex
PRM2
Tbio
Novelty: 0.0050028
p_int: 0.998896602
p_ni: 0.001103398
Data Source: BioPlex
DDX54
Tbio
Family: Enzyme
Novelty: 0.12769464
p_int: 0.998845048
p_ni: 0.001154952
Data Source: BioPlex
CHST8
Tbio
Family: Enzyme
Novelty: 0.03489772
p_int: 0.998558294
p_ni: 0.001441706
Data Source: BioPlex
OSM
Tbio
Novelty: 0.00227405
p_int: 0.998342809
p_ni: 0.001657191
Score: 0.185
Data Source: BioPlex,STRINGDB
GTF3C2
Tdark
Novelty: 0.1827844
p_int: 0.998211402
p_ni: 0.001788598
Score: 0.499
Data Source: BioPlex,STRINGDB
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
p_int: 0.99816549
p_ni: 0.00183451
Data Source: BioPlex
Publication Statistics
PubMed Score  225.81

PubMed score by year
PubTator Score  209.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer