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Tbio
C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

Protein Summary
Description
Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling whi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225698
  • ENSP00000225698
  • ENSG00000108561

Symbol
  • GC1QBP
  • HABP1
  • SF2P32
  • p32
  • HABP1
  • gC1qR
  • GC1QBP
  • SF2p32
  • gC1Q-R
  • COXPD33
  • SF2AP32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
1
kinase perturbation
1
hub protein
0.99
disease perturbation
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.77   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.77   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (242)
BHLHA15
Tbio
Family:  TF
Novelty:  0.02721846
p_int:  0.999643068
p_ni:  0.000356932
Data Source:  BioPlex
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.999631953
p_ni:  0.000368047
Score:  0.499
Data Source:  BioPlex,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.999377402
p_ni:  0.000622598
Data Source:  BioPlex
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.999003094
p_ni:  0.000996906
Data Source:  BioPlex
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.998896602
p_ni:  0.001103398
Data Source:  BioPlex
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.998845048
p_ni:  0.001154952
Data Source:  BioPlex
CHST8
Tbio
Family:  Enzyme
Novelty:  0.03489772
p_int:  0.998558294
p_ni:  0.001441706
Data Source:  BioPlex
OSM
Tbio
Novelty:  0.00227405
p_int:  0.998342809
p_ni:  0.001657191
Score:  0.185
Data Source:  BioPlex,STRINGDB
GTF3C2
Tdark
Novelty:  0.1827844
p_int:  0.998211402
p_ni:  0.001788598
Score:  0.499
Data Source:  BioPlex,STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.99816549
p_ni:  0.00183451
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
2
2
86.1
body mass index
8
3
9
85.2
myeloid white cell count
1
1
1
78.1
leukocyte count
1
1
1
73.9
neutrophil count
2
1
2
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
86.1
body mass index
9
85.2
myeloid white cell count
1
78.1
leukocyte count
1
73.9
neutrophil count
2
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C1q binding protein
VGNC:9226
455252
Macaque
complement C1q binding protein
711817
Mouse
MGI:1194505
12261
Rat
RGD:2230
29681
Dog
complement C1q binding protein
VGNC:38578
489450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C1q binding protein
Macaque
complement C1q binding protein
Mouse
Rat
Dog
complement C1q binding protein
Publication Statistics
PubMed Score 229.77
PubMed score by year
PubTator Score 209.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title