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Tbio
RPL18
60S ribosomal protein L18

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000549920
  • ENSP00000447001
  • ENSG00000063177
  • ENST00000552588
  • ENSP00000449204

Symbol
  • L18
  • DBA18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
gene perturbation
0.94
transcription factor binding site profile
0.93
hub protein
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.5   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.5   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (69)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
7
6
16.2
99.6
low density lipoprotein cholesterol measurement
5
8
12
98.5
apolipoprotein B measurement
2
3
3
95.7
vitamin B12 measurement
3
3
2
70.2
93.8
lymphocyte percentage of leukocytes
2
3
3
93.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
16.2
99.6
low density lipoprotein cholesterol measurement
12
98.5
apolipoprotein B measurement
3
95.7
vitamin B12 measurement
2
70.2
93.8
lymphocyte percentage of leukocytes
3
93.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L18
VGNC:2264
456183
Macaque
ribosomal protein L18
718136
Mouse
MGI:98003
19899
Rat
RGD:621182
81766
Dog
ribosomal protein L18
VGNC:45714
476422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L18
Macaque
ribosomal protein L18
Mouse
Rat
Dog
ribosomal protein L18
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q07020-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (489)
1 – 10 of 489
CEBPZ
Tbio
Novelty:  0.00861664
p_int:  0.999971902
p_ni:  0.000028097
p_wrong:  1e-9
Score:  0.319
Data Source:  BioPlex,STRINGDB
PDCD11
Tbio
Novelty:  0.02209612
p_int:  0.999908856
p_ni:  0.000091144
Score:  0.455
Data Source:  BioPlex,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.999645388
p_ni:  0.000354612
Data Source:  BioPlex
DCAF1
Tbio
Novelty:  0.0170232
p_int:  0.998738775
p_ni:  0.001261225
Data Source:  BioPlex
UBE2O
Tbio
Novelty:  0.07084123
p_int:  0.997047374
p_ni:  0.002952626
Data Source:  BioPlex
NOC2L
Tbio
Novelty:  0.00226536
p_int:  0.995884776
p_ni:  0.004115224
Score:  0.362
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.99372043
p_ni:  0.00627957
Score:  0.241
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.992600334
p_ni:  0.007399666
Score:  0.451
Data Source:  BioPlex,STRINGDB
NLE1
Tbio
Novelty:  0.03831535
p_int:  0.992258501
p_ni:  0.007741498
p_wrong:  1e-9
Score:  0.548
Data Source:  BioPlex,STRINGDB
NSUN4
Tbio
Family:  Enzyme
Novelty:  0.15593771
p_int:  0.987744111
p_ni:  0.012255889
Score:  0.344
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  56.50

PubMed score by year
PubTator Score  16.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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