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Tbio
TNFRSF9
Tumor necrosis factor receptor superfamily member 9

Protein Summary
Description
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377507
  • ENSP00000366729
  • ENSG00000049249
  • ENST00000615230
  • ENSP00000478699

Symbol
  • CD137
  • ILA
  • ILA
  • 4-1BB
  • CD137
  • CDw137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
gene perturbation
0.92
cell type or tissue
0.8
biological term
0.74
tissue
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 713.93   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 994   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 713.93   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 994   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.2
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.2
11.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TNF receptor superfamily member 9
708281
Mouse
MGI:1101059
21942
Rat
RGD:1598208
500590
Dog
TNF receptor superfamily member 9
VGNC:47668
608274
Horse
TNF receptor superfamily member 9
VGNC:50787
100058657
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TNF receptor superfamily member 9
Mouse
Rat
Dog
TNF receptor superfamily member 9
Horse
TNF receptor superfamily member 9
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q07011-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (127)
1 – 10 of 127
CERK
Tchem
Family: Kinase
Novelty: 0.0103948
p_int: 0.996073064
p_ni: 0.003814281
p_wrong: 0.000112655
Score: 0.261
Data Source: BioPlex,STRINGDB
TNFSF9
Tbio
Novelty: 0.00532152
p_int: 0.975536604
p_ni: 0.024463396
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SNX11
Tdark
Novelty: 0.21586113
p_int: 0.974884831
p_ni: 0.025115168
Score: 0.187
Data Source: BioPlex,STRINGDB
ATP12A
Tchem
Family: Transporter
Novelty: 0.00008793
p_int: 0.853224265
p_ni: 0.146775735
Score: 0.158
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.972
Data Source: STRINGDB
MAP3K5
Tchem
Family: Kinase
Novelty: 0.00144614
Score: 0.908
Data Source: STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
Score: 0.843
Data Source: STRINGDB
IL2
Tchem
Novelty: 0.00003129
Score: 0.828
Data Source: STRINGDB
TMEM26
Tdark
Novelty: 0.07174624
Score: 0.823
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.814
Data Source: STRINGDB
Publication Statistics
PubMed Score  713.93

PubMed score by year
PubTator Score  262.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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