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Tchem
CDK18
Cyclin-dependent kinase 18

Protein Summary
Description
May play a role in signal transduction cascades in terminally differentiated cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360066
  • ENSP00000353176
  • ENSG00000117266
  • ENST00000429964
  • ENSP00000399082
  • ENST00000506784
  • ENSP00000423665

Symbol
  • PCTAIRE3
  • PCTK3
  • PCTK3
  • PCTAIRE
  • PCTAIRE3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
0.94
disease perturbation
0.87
gene perturbation
0.8
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.29   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.29   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (128)
1 – 10 of 128
TTC29
Tdark
Novelty: 0.1887357
p_int: 0.999999967
p_ni: 3.1e-8
p_wrong: 2e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
CDK16
Tchem
Family: Kinase
Novelty: 0.02579684
p_int: 0.999999962
p_ni: 1.1e-8
p_wrong: 2.7e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
SFXN2
Tdark
Novelty: 0.34860897
p_int: 0.999977064
p_ni: 0.000022936
Score: 0.395
Data Source: BioPlex,STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
p_int: 0.998720552
p_ni: 0.001279448
Score: 0.298
Data Source: BioPlex,STRINGDB
DUSP7
Tbio
Family: Enzyme
Novelty: 0.05499898
p_int: 0.998168405
p_ni: 0.001831594
p_wrong: 2e-9
Score: 0.329
Data Source: BioPlex,STRINGDB
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.995464643
p_ni: 0.00001214
p_wrong: 0.004523217
Score: 0.867
Data Source: BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int: 0.993545397
p_ni: 0.006454593
p_wrong: 1e-8
Data Source: BioPlex
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.987931711
p_ni: 0.012068277
p_wrong: 1.2e-8
Score: 0.305
Data Source: BioPlex,STRINGDB
CA4
Tclin
Family: Enzyme
Novelty: 0.0004916
p_int: 0.953362943
p_ni: 0.046248258
p_wrong: 0.000388798
Score: 0.417
Data Source: BioPlex,STRINGDB
ACKR2
Tbio
Family: GPCR
Novelty: 0.00412934
p_int: 0.95198665
p_ni: 0.048013319
p_wrong: 3.1e-8
Score: 0.39
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.29

PubMed score by year
PubTator Score  12.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer