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Tbio
SOX4
Transcription factor SOX-4

Protein Summary
Description
Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244745
  • ENSP00000244745
  • ENSG00000124766

Symbol
  • EVI16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
transcription factor perturbation
0.99
molecular function
0.93
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.3   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.3   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (30)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (53)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (84)
1 – 10 of 84
CTNNB1
Tchem
Novelty: 0.00008951
Score: 0.961
Data Source: Reactome,STRINGDB
LEF1
Tchem
Family: TF
Novelty: 0.00223818
Score: 0.948
Data Source: Reactome,STRINGDB
TCF7
Tbio
Family: TF
Novelty: 0.0150836
Score: 0.946
Data Source: STRINGDB
TCF7L2
Tbio
Family: TF
Novelty: 0.00205974
Score: 0.926
Data Source: Reactome,STRINGDB
TCF7L1
Tbio
Family: TF
Novelty: 0.0511399
Score: 0.922
Data Source: STRINGDB
SDCBP
Tbio
Novelty: 0.0034118
Score: 0.839
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.798
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00316288
Score: 0.755
Data Source: STRINGDB
IL5RA
Tclin
Novelty: 0.02117904
Score: 0.712
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00057242
Score: 0.698
Data Source: STRINGDB
Publication Statistics
PubMed Score  238.30

PubMed score by year
PubTator Score  148.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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