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Tbio
EGR3
Early growth response protein 3

Protein Summary
Description
Probable transcription factor involved in muscle spindle development. This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317216
  • ENSP00000318057
  • ENSG00000179388
  • ENST00000522910
  • ENSP00000430310

Symbol
  • PILOT
  • EGR-3
  • PILOT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
biological process
0.94
small molecule perturbation
0.93
PubMedID
0.91
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.39   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.39   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
57.1
Pathways (7)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
C-type lectin receptor signaling pathway
KEGG
Viral carcinogenesis
KEGG
Hepatitis B
Name
Explore in Pharos
Explore in Source
C-type lectin receptor signaling pathway
Viral carcinogenesis
Hepatitis B
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (45)
1 – 10 of 45
EGR2
Tbio
Family: TF
Novelty: 0.00215433
Score: 0.961
Data Source: STRINGDB
GABRA4
Tclin
Family: IC
Novelty: 0.03089903
Score: 0.903
Data Source: STRINGDB
NAB2
Tbio
Novelty: 0.00860107
Score: 0.83
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.699
Data Source: STRINGDB
FOSB
Tbio
Family: TF
Novelty: 0.00183071
Score: 0.687
Data Source: STRINGDB
NAB1
Tbio
Novelty: 0.03811946
Score: 0.675
Data Source: STRINGDB
NRG1
Tbio
Novelty: 0.00095246
Score: 0.669
Data Source: STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.665
Data Source: STRINGDB
EGR1
Tbio
Family: TF
Novelty: 0.00039994
Score: 0.661
Data Source: STRINGDB
NFATC3
Tbio
Family: TF
Novelty: 0.00602983
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  133.39

PubMed score by year
PubTator Score  84.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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