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Tbio
PRDX1
Peroxiredoxin-1

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262746
  • ENSP00000262746
  • ENSG00000117450
  • ENST00000319248
  • ENSP00000361152

Symbol
  • PAGA
  • PAGB
  • TDPX2
  • PAG
  • PAGA
  • PAGB
  • PRX1
  • PRXI
  • MSP23
  • NKEFA
  • TDPX2
  • NKEF-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
virus perturbation
0.98
transcription factor binding site profile
0.97
hub protein
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.03   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 626   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.03   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 626   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Detoxification of Reactive Oxygen Species
Disease
Protein-Protein Interactions (180)
1 – 10 of 180
PRDX3
Tbio
Family: Enzyme
Novelty: 0.00452612
p_int: 0.79152401
p_ni: 0.20847599
Score: 0.885
Data Source: BioPlex,STRINGDB
TXN
Tchem
Novelty: 0.00056085
Score: 0.994
Data Source: Reactome,STRINGDB
SESN2
Tbio
Novelty: 0.00594978
Score: 0.983
Data Source: Reactome,STRINGDB
SRXN1
Tbio
Novelty: 0.00623486
Score: 0.982
Data Source: STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00044941
Score: 0.981
Data Source: STRINGDB
PRDX5
Tbio
Novelty: 0.00501611
Score: 0.978
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013834
Score: 0.968
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00022628
Score: 0.968
Data Source: STRINGDB
GDPD5
Tbio
Family: Enzyme
Novelty: 0.06263048
Score: 0.949
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  448.03

PubMed score by year
PubTator Score  237.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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