Tchem PRDX1 Peroxiredoxin-1

Protein Summary

Description

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q06830
• B5BU26
• D3DPZ8
• P35703
• Q2V576
• Q5T154
• Q5T155

Gene Name

• PRDX1

Ensembl ID

• ENST00000262746
• ENSP00000262746
• ENSG00000117450
• ENST00000319248
• ENSP00000361152

Symbol

• PAGA
• PAGB
• TDPX2
• PAG
• PAGA
• PAGB
• PRX1
• PRXI
• MSP23
• NKEFA
• TDPX2
• NKEF-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
virus perturbation	0.98
transcription factor binding site profile	0.97
hub protein	0.95

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Peroxidase / Peroxiredoxin-1

DTO Classes

Protein / Enzyme / Oxidoreductase / Peroxidase / Peroxiredoxin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.11   (req: < 5)

Gene RIFs: 158   (req: <= 3)

Antibodies: 626   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.11   (req: >= 5)

Gene RIFs: 158   (req: > 3)

Antibodies: 626   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0