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Tbio
PRDX1
Peroxiredoxin-1

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262746
  • ENSP00000262746
  • ENSG00000117450
  • ENST00000319248
  • ENSP00000361152

Symbol
  • PAGA
  • PAGB
  • TDPX2
  • PAG
  • PAGA
  • PAGB
  • PRX1
  • PRXI
  • MSP23
  • NKEFA
  • TDPX2
  • NKEF-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
virus perturbation
0.98
transcription factor binding site profile
0.97
hub protein
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.54   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 626   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.54   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 626   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
1
1
47.9
hemoglobin measurement
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
47.9
hemoglobin measurement
1
13.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxiredoxin 1
VGNC:1469
456537
Macaque
peroxiredoxin 1
706142
Mouse
MGI:99523
18477
Rat
RGD:620039
117254
Dog
peroxiredoxin 1
475375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxiredoxin 1
Macaque
peroxiredoxin 1
Mouse
Rat
Dog
peroxiredoxin 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q06830-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Detoxification of Reactive Oxygen Species
Disease
Protein-Protein Interactions (180)
1 – 10 of 180
PRDX3
Tbio
Family: Enzyme
Novelty: 0.00340119
p_int: 0.79152401
p_ni: 0.20847599
Score: 0.885
Data Source: BioPlex,STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.994
Data Source: Reactome,STRINGDB
SESN2
Tbio
Novelty: 0.00441857
Score: 0.983
Data Source: Reactome,STRINGDB
SRXN1
Tbio
Novelty: 0.00780861
Score: 0.982
Data Source: STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
Score: 0.981
Data Source: STRINGDB
PRDX5
Tbio
Novelty: 0.00369421
Score: 0.978
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.968
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.968
Data Source: STRINGDB
GDPD5
Tbio
Family: Enzyme
Novelty: 0.05871733
Score: 0.949
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  548.54

PubMed score by year
PubTator Score  237.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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