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Tbio
FMOD
Fibromodulin

Protein Summary
Description
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354955
  • ENSP00000347041
  • ENSG00000122176

Symbol
  • FM
  • SLRR2E
  • FM
  • SLRR2E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
gene perturbation
0.77
disease perturbation
0.68
small molecule perturbation
0.67
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.49   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.49   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibromodulin
VGNC:10644
457644
Macaque
fibromodulin
703048
Mouse
MGI:1328364
14264
Rat
RGD:619769
64507
Dog
fibromodulin
VGNC:40921
488560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibromodulin
Macaque
fibromodulin
Mouse
Rat
Dog
fibromodulin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q06828-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Reactome
Defective CHST6 causes MCDC1
Reactome
Defective ST3GAL3 causes MCT12 and EIEE15
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (129)
1 – 10 of 129
S100A7A
Tbio
Novelty: 0.06518939
p_int: 0.999995588
p_ni: 0.000004408
p_wrong: 4e-9
Data Source: BioPlex
LRRC15
Tbio
Novelty: 0.03701624
p_int: 0.997491361
p_ni: 0.000071558
p_wrong: 0.002437081
Score: 0.373
Data Source: BioPlex,STRINGDB
CTSF
Tchem
Family: Enzyme
Novelty: 0.01359417
p_int: 0.982860215
p_ni: 0.01699261
p_wrong: 0.000147176
Data Source: BioPlex
UGT8
Tbio
Family: Enzyme
Novelty: 0.02518383
p_int: 0.924718373
p_ni: 0.075281627
Data Source: BioPlex
S100A7
Tbio
Novelty: 0.00434262
p_int: 0.817983631
p_ni: 0.182016369
Data Source: BioPlex
SERPINB4
Tbio
Novelty: 0.00522283
p_int: 0.802574865
p_ni: 0.197425135
Data Source: BioPlex
ACAN
Tbio
Novelty: 0.00033695
Score: 0.981
Data Source: STRINGDB
TGFB3
Tbio
Novelty: 0.00068568
Score: 0.955
Data Source: Reactome,STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.949
Data Source: Reactome,STRINGDB
TGFB2
Tbio
Novelty: 0.00050804
Score: 0.945
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  216.49

PubMed score by year
PubTator Score  134.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer