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Tbio
FMR1
Synaptic functional regulator FMR1

Protein Summary
Description
Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs (PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218200
  • ENSP00000218200
  • ENSG00000102081
  • ENST00000370470
  • ENSP00000359501
  • ENST00000370471
  • ENSP00000359502
  • ENST00000370475
  • ENSP00000359506
  • ENST00000440235
  • ENSP00000413764

Symbol
  • POF
  • FMRP
  • POF1
  • FRAXA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
interacting protein
0.95
kinase perturbation
0.88
biological term
0.82
microRNA
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3550.3   (req: < 5)
Gene RIFs: 490   (req: <= 3)
Antibodies: 655   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3550.3   (req: >= 5)
Gene RIFs: 490   (req: > 3)
Antibodies: 655   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (243)
KBTBD2
Tdark
Novelty:  0.50755656
p_int:  0.999999817
p_ni:  1.81e-7
p_wrong:  2e-9
Score:  0.431
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.998517982
p_ni:  0.001482018
Score:  0.307
Data Source:  BioPlex,STRINGDB
FXR2
Tbio
Family:  Epigenetic
Novelty:  0.0253623
p_int:  0.997928117
p_ni:  0.002071883
Score:  0.949
Data Source:  BioPlex,STRINGDB
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.992269532
p_ni:  0.007730468
Data Source:  BioPlex
BCL7B
Tbio
Novelty:  0.11909054
p_int:  0.960351292
p_ni:  0.006211509
p_wrong:  0.033437199
Score:  0.232
Data Source:  BioPlex,STRINGDB
WBP2NL
Tbio
Novelty:  0.03957932
p_int:  0.867418446
p_ni:  0.132581554
Score:  0.345
Data Source:  BioPlex,STRINGDB
CYFIP1
Tbio
Novelty:  0.01758346
Score:  0.989
Data Source:  STRINGDB
CYFIP2
Tbio
Novelty:  0.01910939
Score:  0.973
Data Source:  STRINGDB
FXR1
Tbio
Novelty:  0.01279428
Score:  0.952
Data Source:  STRINGDB
AGO1
Tbio
Novelty:  0.00157424
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (108)
Find Similar Targets
Items per page:
10
1 – 10 of 24
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
8.1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
8.1
7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fragile X mental retardation 1
VGNC:1386
465894
Macaque
fragile X mental retardation 1
700138
Mouse
MGI:95564
14265
Rat
RGD:2623
24948
Dog
fragile X mental retardation 1
VGNC:40922
481070
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fragile X mental retardation 1
Macaque
fragile X mental retardation 1
Mouse
Rat
Dog
fragile X mental retardation 1
Publication Statistics
PubMed Score 3550.30
PubMed score by year
PubTator Score 1959.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title