Protein Summary
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by ...more
- ENST00000376117
- ENSP00000365285
- ENSG00000204487
- ENST00000383493
- ENSP00000372985
- ENSG00000206437
- ENST00000420402
- ENSP00000398741
- ENSG00000223448
- ENST00000421268
- ENSP00000393693
- ENSG00000238114
- ENST00000429299
- ENSP00000410481
- ENSG00000227507
- ENST00000444479
- ENSP00000395102
- ENSG00000236925
- ENST00000446745
- ENSP00000416113
- ENST00000456113
- ENSP00000404014
- ENSG00000236237
- ENST00000457552
- ENSP00000404450
- ENSG00000231314
- TNFC
- TNFSF3
- p33
- TNFC
- TNFSF3
- TNLG1C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.98 | ||
gene perturbation | 0.89 | ||
protein domain | 0.73 | ||
phenotype | 0.59 | ||
tissue sample | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 189.88 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 189.88 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0