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Tchem
RAD51
DNA repair protein RAD51 homolog 1

Protein Summary
Description
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028). The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267868
  • ENSP00000267868
  • ENSG00000051180
  • ENST00000382643
  • ENSP00000372088
  • ENST00000423169
  • ENSP00000406602
  • ENST00000532743
  • ENSP00000433924
  • ENST00000557850
  • ENSP00000454176

Symbol
  • RAD51A
  • RECA
  • RECA
  • BRCC5
  • FANCR
  • MRMV2
  • HRAD51
  • RAD51A
  • HsRad51
  • HsT16930
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
molecular function
0.99
protein domain
0.99
histone modification site profile
0.93
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8972.68   (req: < 5)
Gene RIFs: 384   (req: <= 3)
Antibodies: 824   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8972.68   (req: >= 5)
Gene RIFs: 384   (req: > 3)
Antibodies: 824   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
65.8
mean corpuscular volume
1
1
1
44.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
65.8
mean corpuscular volume
1
44.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD51 recombinase
VGNC:1893
453339
Macaque
RAD51 recombinase
708579
Mouse
MGI:97890
19361
Rat
RGD:1563603
499870
Dog
RAD51 recombinase
VGNC:45317
403568
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD51 recombinase
Macaque
RAD51 recombinase
Mouse
Rat
Dog
RAD51 recombinase
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q06609-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cell Cycle
DNA Double-Strand Break Repair
DNA Repair
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (52)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (568)
1 – 10 of 568
DMC1
Tbio
Novelty: 0.05445277
p_int: 0.999991381
p_ni: 0.000008589
p_wrong: 3e-8
Score: 0.979
Data Source: BioPlex,STRINGDB
FIGNL1
Tbio
Family: Enzyme
Novelty: 0.10817841
p_int: 0.999887482
p_ni: 0.000112514
p_wrong: 4e-9
Score: 0.596
Data Source: BioPlex,STRINGDB
TSGA10IP
Tdark
Novelty: 20.75428866
p_int: 0.999086823
p_ni: 0.000908411
p_wrong: 0.000004766
Data Source: BioPlex
SNX32
Tdark
Novelty: 0.66136036
p_int: 0.997337567
p_ni: 0.002662431
p_wrong: 2e-9
Score: 0.221
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.988268337
p_ni: 0.011731663
Score: 0.195
Data Source: BioPlex,STRINGDB
HASPIN
Tchem
Family: Kinase
Novelty: 0.01574198
p_int: 0.983752938
p_ni: 0.016236848
p_wrong: 0.000010214
Score: 0.213
Data Source: BioPlex,STRINGDB
TEAD1
Tbio
Family: TF
Novelty: 0.01198524
p_int: 0.977951525
p_ni: 0.022046363
p_wrong: 0.000002111
Score: 0.513
Data Source: BioPlex,STRINGDB
MYCBP2
Tbio
Family: Enzyme
Novelty: 0.00413684
p_int: 0.936640304
p_ni: 0.063359696
Score: 0.325
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.920361873
p_ni: 0.079638127
Score: 0.183
Data Source: BioPlex,STRINGDB
KHDC1
Tbio
Novelty: 0.13778027
p_int: 0.909716882
p_ni: 0.090222166
p_wrong: 0.000060952
Data Source: BioPlex
Publication Statistics
PubMed Score  8972.68

PubMed score by year
PubTator Score  2210.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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