Tbio RING1 E3 ubiquitin-protein ligase RING1

Protein Summary

Description

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q06587
• A8JZZ0
• Q5JP96
• Q5SQW2
• Q86V19

Gene Name

• RING1

Ensembl ID

• ENST00000374656
• ENSP00000363787
• ENSG00000204227
• ENST00000383212
• ENSP00000372699
• ENSG00000206287
• ENST00000415941
• ENSP00000412190
• ENSG00000226788
• ENST00000427374
• ENSP00000400572
• ENSG00000231115
• ENST00000430233
• ENSP00000396271
• ENSG00000228520
• ENST00000436128
• ENSP00000396439
• ENSG00000235107

Symbol

• RNF1
• RNF1
• RING1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
interacting protein	0.87
cell type or tissue	0.8
cellular component	0.8
tissue sample	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.63   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 538   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.63   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 538   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0