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Tbio
GABPB1
GA-binding protein subunit beta-1

Protein Summary
Description
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220429
  • ENSP00000220429
  • ENSG00000104064
  • ENST00000359031
  • ENSP00000351923
  • ENST00000380877
  • ENSP00000370259
  • ENST00000396464
  • ENSP00000379728
  • ENST00000429662
  • ENSP00000395771

Symbol
  • E4TF1B
  • GABPB
  • GABPB2
  • E4TF1
  • GABPB
  • BABPB2
  • E4TF1B
  • GABPB2
  • NRF2B1
  • NRF2B2
  • GABPB-1
  • E4TF1-47
  • E4TF1-53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.94
transcription factor binding site profile
0.87
trait
0.86
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.98   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.98   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
GABPA
Tbio
Family:  TF
Novelty:  0.01731451
p_int:  0.999999995
p_ni:  5e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
TDRD7
Tbio
Family:  Epigenetic
Novelty:  0.03580848
p_int:  0.999999977
p_ni:  1.5e-8
p_wrong:  8e-9
Score:  0.659
Data Source:  BioPlex,STRINGDB
TPD52L2
Tbio
Novelty:  0.03500169
p_int:  0.999123299
p_ni:  0.000876701
Score:  0.859
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
Score:  0.974
Data Source:  STRINGDB
TUBA1B
Tchem
Novelty:  0.02465964
Score:  0.961
Data Source:  STRINGDB
TUBB2B
Tclin
Novelty:  0.02905844
Score:  0.96
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.96
Data Source:  STRINGDB
STMN4
Tbio
Novelty:  0.00422625
Score:  0.96
Data Source:  STRINGDB
KIF5B
Tbio
Novelty:  0.00515256
Score:  0.959
Data Source:  STRINGDB
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Mitochondrial biogenesis (R-HSA-1592230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
1
2
71.5
blood metabolite measurement
1
1
1
60.5
platelet crit
1
1
1
59
platelet count
1
1
1
53.7
mean reticulocyte volume
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
71.5
blood metabolite measurement
1
60.5
platelet crit
1
59
platelet count
1
53.7
mean reticulocyte volume
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GA binding protein transcription factor, beta subunit 1
453426
Macaque
GA binding protein transcription factor beta subunit 1
715334
Mouse
MGI:95611
14391
Rat
RGD:1310235
364738
Dog
GA binding protein transcription factor subunit beta 1
VGNC:41051
608465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GA binding protein transcription factor, beta subunit 1
Macaque
GA binding protein transcription factor beta subunit 1
Mouse
Rat
Dog
GA binding protein transcription factor subunit beta 1
Publication Statistics
PubMed Score 53.98
PubMed score by year
PubTator Score 39.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title