You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GABPA
GA-binding protein alpha chain

Protein Summary
Description
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354828
  • ENSP00000346886
  • ENSG00000154727
  • ENST00000400075
  • ENSP00000382948

Symbol
  • E4TF1A
  • NFT2
  • NRF2
  • NRF2A
  • E4TF1A
  • E4TF1-60
  • RCH04A07
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
protein domain
0.92
histone modification site profile
0.87
transcription factor binding site profile
0.87
biological process
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.16   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.16   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GA binding protein transcription factor subunit alpha
VGNC:3733
474079
Macaque
GA binding protein transcription factor alpha subunit
708312
Mouse
MGI:95610
14390
Rat
RGD:1310802
363735
Dog
GA binding protein transcription factor subunit alpha
VGNC:41050
478394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GA binding protein transcription factor subunit alpha
Macaque
GA binding protein transcription factor alpha subunit
Mouse
Rat
Dog
GA binding protein transcription factor subunit alpha
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q06546-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Mitochondrial biogenesis (R-HSA-1592230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Gene Ontology Terms (24)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (85)
1 – 10 of 85
GABPB1
Tbio
Novelty: 0.01518726
p_int: 0.999999995
p_ni: 5e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
GABPB2
Tbio
Novelty: 0.52630478
p_int: 0.999999995
p_ni: 5e-9
Score: 0.911
Data Source: BioPlex,STRINGDB
TPD52L2
Tbio
Novelty: 0.03500169
p_int: 0.981040037
p_ni: 0.018896876
p_wrong: 0.000063087
Score: 0.823
Data Source: BioPlex,STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
p_int: 0.885002975
p_ni: 0.114931188
p_wrong: 0.000065837
Score: 0.222
Data Source: BioPlex,STRINGDB
TFAM
Tbio
Family: TF
Novelty: 0.00131608
Score: 0.971
Data Source: STRINGDB
PPRC1
Tbio
Novelty: 0.00182088
Score: 0.962
Data Source: STRINGDB
NRF1
Tbio
Family: TF
Novelty: 0.00543248
Score: 0.957
Data Source: STRINGDB
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.946
Data Source: STRINGDB
HCFC1
Tbio
Novelty: 0.00440762
Score: 0.946
Data Source: STRINGDB
TFB1M
Tbio
Family: Enzyme
Novelty: 0.0236373
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.16

PubMed score by year
PubTator Score  58.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: