SULT2A1
Bile salt sulfotransferase
Protein Summary
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]
- ENST00000222002
- ENSP00000222002
- ENSG00000105398
- HST
- STD
- HST
- ST2
- STD
- hSTa
- DHEAS
- ST2A1
- ST2A3
- DHEA-ST
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.76 | ||
cell type or tissue | 0.68 | ||
disease | 0.68 | ||
virus perturbation | 0.64 | ||
kinase perturbation | 0.6 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 221.66 (req: < 5)
Gene RIFs: 44 (req: <= 3)
Antibodies: 411 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 221.66 (req: >= 5)
Gene RIFs: 44 (req: > 3)
Antibodies: 411 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 6 | 4 | 7 | 99.8 | |||||
blood metabolite measurement | 2 | 1 | 4 | 89.2 | |||||
gallstones | 1 | 1 | 0 | 1.2 | 82.8 | ||||
dehydroepiandrosterone sulphate measurement | 1 | 3 | 5 | 73.8 | |||||
estradiol measurement | 1 | 1 | 1 | 68.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 7 | 99.8 | |||||
blood metabolite measurement | 4 | 89.2 | |||||
gallstones | 0 | 1.2 | 82.8 | ||||
dehydroepiandrosterone sulphate measurement | 5 | 73.8 | |||||
estradiol measurement | 1 | 68.4 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sulfotransferase family 2A member 1 | VGNC:13520 | 456409 | |||||
Macaque | sulfotransferase family 2A member 1 | 717600 | ||||||
Mouse | MGI:3645873 | 629203 | ||||||
Mouse | MGI:3648915 | 629219 | ||||||
Rat | ||||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sulfotransferase family 2A member 1 | |||||
Macaque | sulfotransferase family 2A member 1 | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (21)
Reactome (7)
KEGG (3)
PathwayCommons (1)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytosolic sulfonation of small molecules | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PPARA activates gene expression | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytosolic sulfonation of small molecules | ||||
Metabolism | ||||
Metabolism of lipids | ||||
PPARA activates gene expression | ||||
Gene Ontology Terms (13)
Functions (5)
Components (1)
Processes (7)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | GO_Central | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (136)
1 – 10 of 136
CYP2B6
Novelty: 0.00018351
Score: 0.947
Data Source: STRINGDB
CYP1A1
Novelty: 0.0002404
Score: 0.934
Data Source: STRINGDB
CYP1B1
Novelty: 0.00090917
Score: 0.928
Data Source: STRINGDB
PPARA
Family: NR
Novelty: 0.00017403
Score: 0.927
Data Source: STRINGDB
FABP1
Novelty: 0.00192691
Score: 0.923
Data Source: STRINGDB
SHBG
Novelty: 0.00015978
Score: 0.921
Data Source: STRINGDB
RXRA
Family: NR
Novelty: 0.00244343
Score: 0.921
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
Score: 0.911
Data Source: STRINGDB
NCOA6
Novelty: 0.00750424
Score: 0.909
Data Source: STRINGDB
NCOA2
Novelty: 0.00510052
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score 221.66
PubMed score by year
PubTator Score 1272.86
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword