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Tbio
SULT2A1
Bile salt sulfotransferase

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222002
  • ENSP00000222002
  • ENSG00000105398

Symbol
  • HST
  • STD
  • HST
  • ST2
  • STD
  • hSTa
  • DHEAS
  • ST2A1
  • ST2A3
  • DHEA-ST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.76
cell type or tissue
0.68
disease
0.68
virus perturbation
0.64
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.66   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.66   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
6
4
7
99.8
blood metabolite measurement
2
1
4
89.2
gallstones
1
1
0
1.2
82.8
dehydroepiandrosterone sulphate measurement
1
3
5
73.8
estradiol measurement
1
1
1
68.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
7
99.8
blood metabolite measurement
4
89.2
gallstones
0
1.2
82.8
dehydroepiandrosterone sulphate measurement
5
73.8
estradiol measurement
1
68.4
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Metabolism of lipids
PPARA activates gene expression
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (136)
1 – 10 of 136
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.947
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.934
Data Source: STRINGDB
CYP1B1
Tchem
Novelty: 0.00090917
Score: 0.928
Data Source: STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.927
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.923
Data Source: STRINGDB
SHBG
Tchem
Novelty: 0.00015978
Score: 0.921
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.921
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.911
Data Source: STRINGDB
NCOA6
Tbio
Novelty: 0.00750424
Score: 0.909
Data Source: STRINGDB
NCOA2
Tbio
Novelty: 0.00510052
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  221.66

PubMed score by year
PubTator Score  1272.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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