SULT2A1
Bile salt sulfotransferase
Protein Summary
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]
- ENST00000222002
- ENSP00000222002
- ENSG00000105398
- HST
- STD
- HST
- ST2
- STD
- hSTa
- DHEAS
- ST2A1
- ST2A3
- DHEA-ST
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.76 | ||
cell type or tissue | 0.68 | ||
disease | 0.68 | ||
virus perturbation | 0.64 | ||
kinase perturbation | 0.6 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 221.66 (req: < 5)
Gene RIFs: 44 (req: <= 3)
Antibodies: 411 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 221.66 (req: >= 5)
Gene RIFs: 44 (req: > 3)
Antibodies: 411 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 6 | 4 | 7 | 99.8 | |||||
blood metabolite measurement | 2 | 1 | 4 | 89.2 | |||||
gallstones | 1 | 1 | 0 | 1.2 | 82.8 | ||||
dehydroepiandrosterone sulphate measurement | 1 | 3 | 5 | 73.8 | |||||
estradiol measurement | 1 | 1 | 1 | 68.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 7 | 99.8 | |||||
blood metabolite measurement | 4 | 89.2 | |||||
gallstones | 0 | 1.2 | 82.8 | ||||
dehydroepiandrosterone sulphate measurement | 5 | 73.8 | |||||
estradiol measurement | 1 | 68.4 | |||||
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (21)
Reactome (7)
KEGG (3)
PathwayCommons (1)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytosolic sulfonation of small molecules | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PPARA activates gene expression | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytosolic sulfonation of small molecules | ||||
Metabolism | ||||
Metabolism of lipids | ||||
PPARA activates gene expression | ||||
Gene Ontology Terms (13)
Functions (5)
Components (1)
Processes (7)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | GO_Central | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (136)
1 – 10 of 136
CYP2B6
Novelty: 0.00018351
Score: 0.947
Data Source: STRINGDB
CYP1A1
Novelty: 0.0002404
Score: 0.934
Data Source: STRINGDB
CYP1B1
Novelty: 0.00090917
Score: 0.928
Data Source: STRINGDB
PPARA
Family: NR
Novelty: 0.00017403
Score: 0.927
Data Source: STRINGDB
FABP1
Novelty: 0.00192691
Score: 0.923
Data Source: STRINGDB
SHBG
Novelty: 0.00015978
Score: 0.921
Data Source: STRINGDB
RXRA
Family: NR
Novelty: 0.00244343
Score: 0.921
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
Score: 0.911
Data Source: STRINGDB
NCOA6
Novelty: 0.00750424
Score: 0.909
Data Source: STRINGDB
NCOA2
Novelty: 0.00510052
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score 221.66
PubMed score by year
PubTator Score 1272.86
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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