Tbio SULT2A1 Bile salt sulfotransferase

Protein Summary

Description

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q06520

Gene Name

• SULT2A1

Ensembl ID

• ENST00000222002
• ENSP00000222002
• ENSG00000105398

Symbol

• HST
• STD
• HST
• ST2
• STD
• hSTa
• DHEAS
• ST2A1
• ST2A3
• DHEA-ST

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.76
cell type or tissue	0.68
disease	0.68
virus perturbation	0.64
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.45   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 411   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.45   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0