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Tbio
SLC34A1
Sodium-dependent phosphate transport protein 2A

Protein Summary
Description
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324417
  • ENSP00000321424
  • ENSG00000131183
  • ENST00000512593
  • ENSP00000423022

Symbol
  • NPT2
  • SLC17A2
  • NPT2
  • FRTS2
  • SLC11
  • HCINF2
  • NAPI-3
  • NPTIIa
  • NPHLOP1
  • SLC17A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
molecular function
0.76
cellular component
0.66
cell type or tissue
0.61
tissue sample
0.6


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.09   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.09   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
5
8
15.2
95
creatinine measurement
4
3
4
86.5
hematocrit
2
2
2
68.1
phosphorus measurement
1
1
1
64.2
red blood cell density measurement
1
1
1
54.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
15.2
95
creatinine measurement
4
86.5
hematocrit
2
68.1
phosphorus measurement
1
64.2
red blood cell density measurement
1
54.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 34 member 1
VGNC:13589
462303
Macaque
solute carrier family 34 member 1
699746
Mouse
MGI:1345284
20505
Rat
RGD:3708
25548
Dog
solute carrier family 34 member 1
VGNC:46358
479275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 34 member 1
Macaque
solute carrier family 34 member 1
Mouse
Rat
Dog
solute carrier family 34 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q06495-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) (R-HSA-5619040)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Metabolism of proteins
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)
Disease
Disorders of transmembrane transporters
Metabolism of proteins
SLC transporter disorders
Gene Ontology Terms (48)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (65)
1 – 10 of 65
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.00357766
Score: 0.838
Data Source: STRINGDB
FGF23
Tclin
Novelty: 0.00047318
Score: 0.826
Data Source: STRINGDB
SLC17A1
Tbio
Family: Transporter
Novelty: 0.0127372
Score: 0.823
Data Source: STRINGDB
PFN3
Tdark
Novelty: 0.11291078
Score: 0.809
Data Source: STRINGDB
SLC20A2
Tbio
Family: Transporter
Novelty: 0.00387767
Score: 0.791
Data Source: STRINGDB
SLC20A1
Tbio
Family: Transporter
Novelty: 0.01123373
Score: 0.787
Data Source: STRINGDB
PDZD3
Tbio
Novelty: 0.08821289
Score: 0.768
Data Source: STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.732
Data Source: STRINGDB
PDZK1
Tbio
Novelty: 0.01129974
Score: 0.724
Data Source: STRINGDB
STC2
Tbio
Novelty: 0.00965684
Score: 0.711
Data Source: STRINGDB
Publication Statistics
PubMed Score  112.09

PubMed score by year
PubTator Score  65.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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