Tbio RUNX1T1 Protein CBFA2T1

Protein Summary

Description

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q06455
• B7Z4P4
• E7EPN4
• O14784
• Q06456
• Q14873
• Q16239
• Q16346
• Q16347
• Q6IBL1
• Q6NXH1
• Q7Z4J5
• Q92479
• Q9BRZ0

Gene Name

• RUNX1T1

Ensembl ID

• ENST00000265814
• ENSP00000265814
• ENSG00000079102
• ENST00000360348
• ENSP00000353504
• ENST00000396218
• ENSP00000379520
• ENST00000422361
• ENSP00000390137
• ENST00000518844
• ENSP00000430728
• ENST00000520724
• ENSP00000428742
• ENST00000523629
• ENSP00000428543
• ENST00000613302
• ENSP00000481799
• ENST00000613886
• ENSP00000478331
• ENST00000614812
• ENSP00000481315
• ENST00000617740
• ENSP00000481112

Symbol

• AML1T1
• CBFA2T1
• CDR
• ETO
• MTG8
• ZMYND2
• CDR
• ETO
• MTG8
• AML1T1
• ZMYND2
• CBFA2T1
• AML1-MTG8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.91
transcription factor	0.84
biological term	0.83
kinase perturbation	0.76
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Protein Cbfa2t1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Protein Cbfa2t1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.85   (req: < 5)

Gene RIFs: 137   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.85   (req: >= 5)

Gene RIFs: 137   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0