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Tbio
RUNX1T1
Protein CBFA2T1

Protein Summary
Description
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265814
  • ENSP00000265814
  • ENSG00000079102
  • ENST00000360348
  • ENSP00000353504
  • ENST00000396218
  • ENSP00000379520
  • ENST00000422361
  • ENSP00000390137
  • ENST00000518844
  • ENSP00000430728
  • ENST00000520724
  • ENSP00000428742
  • ENST00000523629
  • ENSP00000428543
  • ENST00000613302
  • ENSP00000481799
  • ENST00000613886
  • ENSP00000478331
  • ENST00000614812
  • ENSP00000481315
  • ENST00000617740
  • ENSP00000481112

Symbol
  • AML1T1
  • CBFA2T1
  • CDR
  • ETO
  • MTG8
  • ZMYND2
  • CDR
  • ETO
  • MTG8
  • AML1T1
  • ZMYND2
  • CBFA2T1
  • AML1-MTG8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
transcription factor
0.84
biological term
0.83
kinase perturbation
0.76
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.54   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.54   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
93.7
alcohol consumption measurement
3
2
3
85.9
alcohol use disorder measurement
1
1
1
45.5
risk-taking behaviour
1
1
1
19.7
intelligence
1
1
1
17.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
93.7
alcohol consumption measurement
3
85.9
alcohol use disorder measurement
1
45.5
risk-taking behaviour
1
19.7
intelligence
1
17.1
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (143)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Acute myeloid leukemia
KEGG
Transcriptional misregulation in cancer
KEGG
Pathways in cancer
Name
Explore in Pharos
Explore in Source
Acute myeloid leukemia
Transcriptional misregulation in cancer
Pathways in cancer
Protein-Protein Interactions (106)
1 – 10 of 106
PRDM14
Tbio
Family: TF; Epigenetic
Novelty: 0.01776592
p_int: 0.99999998
p_ni: 1e-8
p_wrong: 1e-8
Score: 0.428
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
p_int: 0.999999976
p_ni: 8e-9
p_wrong: 1.6e-8
Score: 0.854
Data Source: BioPlex,STRINGDB
SYCE3
Tdark
Novelty: 0.22361224
p_int: 0.99999949
p_ni: 5.09e-7
p_wrong: 1e-9
Data Source: BioPlex
PSMC5
Tbio
Family: Enzyme
Novelty: 0.01634039
p_int: 0.999988223
p_ni: 0.000011775
p_wrong: 2e-9
Score: 0.156
Data Source: BioPlex,STRINGDB
BSPRY
Tdark
Novelty: 0.38200913
p_int: 0.957015543
p_ni: 0.000765569
p_wrong: 0.042218888
Score: 0.19
Data Source: BioPlex,STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00381424
Score: 0.98
Data Source: STRINGDB
PRKAR2A
Tbio
Family: Enzyme
Novelty: 0.06183318
Score: 0.964
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
Score: 0.945
Data Source: STRINGDB
CEBPA
Tbio
Family: TF
Novelty: 0.00056459
Score: 0.92
Data Source: STRINGDB
SPI1
Tbio
Family: TF
Novelty: 0.00064309
Score: 0.878
Data Source: STRINGDB
Publication Statistics
PubMed Score  312.54

PubMed score by year
PubTator Score  570.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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