Protein Summary
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the ...more
- ENST00000265814
- ENSP00000265814
- ENSG00000079102
- ENST00000360348
- ENSP00000353504
- ENST00000396218
- ENSP00000379520
- ENST00000422361
- ENSP00000390137
- ENST00000518844
- ENSP00000430728
- ENST00000520724
- ENSP00000428742
- ENST00000523629
- ENSP00000428543
- ENST00000613302
- ENSP00000481799
- ENST00000613886
- ENSP00000478331
- ENST00000614812
- ENSP00000481315
- ENST00000617740
- ENSP00000481112
- AML1T1
- CBFA2T1
- CDR
- ETO
- MTG8
- ZMYND2
- CDR
- ETO
- MTG8
- AML1T1
- ZMYND2
- CBFA2T1
- AML1-MTG8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.91 | ||
transcription factor | 0.84 | ||
biological term | 0.83 | ||
kinase perturbation | 0.76 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 321.38 (req: < 5)
Gene RIFs: 104 (req: <= 3)
Antibodies: 256 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 321.38 (req: >= 5)
Gene RIFs: 104 (req: > 3)
Antibodies: 256 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (106)
PRDM14
Family: TF; Epigenetic
Novelty: 0.01776592
p_int: 0.99999998
p_ni: 1e-8
p_wrong: 1e-8
Score: 0.428
Data Source: BioPlex,STRINGDB
TCF4
Family: TF
Novelty: 0.0019718
p_int: 0.999999976
p_ni: 8e-9
p_wrong: 1.6e-8
Score: 0.854
Data Source: BioPlex,STRINGDB
PSMC5
Family: Enzyme
Novelty: 0.01634039
p_int: 0.999988223
p_ni: 0.000011775
p_wrong: 2e-9
Score: 0.156
Data Source: BioPlex,STRINGDB
BSPRY
Novelty: 0.38200913
p_int: 0.957015543
p_ni: 0.000765569
p_wrong: 0.042218888
Score: 0.19
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (143)
KEGG (3)
WikiPathways (140)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Acute myeloid leukemia | ||||
KEGG | Transcriptional misregulation in cancer | ||||
KEGG | Pathways in cancer | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Acute myeloid leukemia | ||||
Transcriptional misregulation in cancer | ||||
Pathways in cancer | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (4)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 3 | 4 | 77.9 | |||||
intelligence | 2 | 4 | 2 | 7.3 | 72.9 | ||||
alcohol consumption measurement | 3 | 2 | 3 | 60.8 | |||||
risk-taking behaviour | 2 | 3 | 3 | 56.8 | |||||
mathematical ability | 2 | 2 | 2 | 46 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
smoking status measurement | 4 | 77.9 | |||||
intelligence | 2 | 7.3 | 72.9 | ||||
alcohol consumption measurement | 3 | 60.8 | |||||
risk-taking behaviour | 3 | 56.8 | |||||
mathematical ability | 2 | 46 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | RUNX1 translocation partner 1 | VGNC:14581 | 472816 | |||||
Macaque | RUNX1 translocation partner 1 | 696934 | ||||||
Mouse | MGI:104793 | 12395 | ||||||
Rat | RGD:1305490 | 362489 | ||||||
Dog | RUNX1 translocation partner 1 | 487044 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | RUNX1 translocation partner 1 | |||||
Macaque | RUNX1 translocation partner 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | RUNX1 translocation partner 1 | |||||
Publication Statistics
PubMed Score 321.38
PubMed score by year
PubTator Score 570.25
PubTator score by year
Related Publications
Text Mined References (146)
GeneRif Annotations (104)
Items per page:
0 of 0
PMID | Year | Title |
---|