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Tbio
CACNG1
Voltage-dependent calcium channel gamma-1 subunit

Protein Summary
Description
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226021
  • ENSP00000226021
  • ENSG00000108878

Symbol
  • CACNLG
  • CACNLG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
gene perturbation
0.71
cell line
0.55
small molecule perturbation
0.52
drug
0.51


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 1
VGNC:9144
741106
Macaque
calcium voltage-gated channel auxiliary subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:1405]
Mouse
MGI:1206582
12299
Rat
RGD:2249
29658
Dog
calcium voltage-gated channel auxiliary subunit gamma 1
VGNC:38647
610892
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 1
Macaque
calcium voltage-gated channel auxiliary subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:1405]
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit gamma 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q06432-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (61)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Protein-Protein Interactions (122)
1 – 10 of 122
IGSF3
Tbio
Novelty: 0.07528465
p_int: 0.999999445
p_ni: 5.56e-7
Data Source: BioPlex
ALG5
Tbio
Family: Enzyme
Novelty: 0.04358658
p_int: 0.999726941
p_ni: 0.000273059
Data Source: BioPlex
CCDC51
Tdark
Novelty: 1.19203634
p_int: 0.99812024
p_ni: 0.001879282
p_wrong: 4.78e-7
Data Source: BioPlex
CYB5R1
Tbio
Family: Enzyme
Novelty: 0.07714146
p_int: 0.997649266
p_ni: 0.002350734
p_wrong: 1e-9
Data Source: BioPlex
XPO4
Tbio
Novelty: 0.01507446
p_int: 0.991859011
p_ni: 0.008140989
Data Source: BioPlex
RAB4A
Tbio
Family: Enzyme
Novelty: 0.00423197
p_int: 0.990117486
p_ni: 0.001801737
p_wrong: 0.008080777
Data Source: BioPlex
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.989286331
p_ni: 0.010713662
p_wrong: 7e-9
Data Source: BioPlex
SMPD2
Tchem
Family: Enzyme
Novelty: 0.00375744
p_int: 0.985279493
p_ni: 0.014681253
p_wrong: 0.000039253
Data Source: BioPlex
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01137558
p_int: 0.977002144
p_ni: 0.006892673
p_wrong: 0.016105183
Data Source: BioPlex
AACS
Tbio
Family: Enzyme
Novelty: 0.01297361
p_int: 0.970275002
p_ni: 6.1e-8
p_wrong: 0.029724937
Data Source: BioPlex
Publication Statistics
PubMed Score  7.11

PubMed score by year
PubTator Score  5.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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