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Tbio
CACNG1
Voltage-dependent calcium channel gamma-1 subunit

Protein Summary
Description
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226021
  • ENSP00000226021
  • ENSG00000108878

Symbol
  • CACNLG
  • CACNLG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
gene perturbation
0.71
cell line
0.55
small molecule perturbation
0.52
drug
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
IGSF3
Tbio
Novelty:  0.07528465
p_int:  0.999999445
p_ni:  5.56e-7
Data Source:  BioPlex
ALG5
Tbio
Family:  Enzyme
Novelty:  0.04358658
p_int:  0.999726941
p_ni:  0.000273059
Data Source:  BioPlex
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.99812024
p_ni:  0.001879282
p_wrong:  4.78e-7
Data Source:  BioPlex
CYB5R1
Tbio
Family:  Enzyme
Novelty:  0.07714146
p_int:  0.997649266
p_ni:  0.002350734
p_wrong:  1e-9
Data Source:  BioPlex
XPO4
Tbio
Novelty:  0.01507446
p_int:  0.991859011
p_ni:  0.008140989
Data Source:  BioPlex
RAB4A
Tbio
Family:  Enzyme
Novelty:  0.00423197
p_int:  0.990117486
p_ni:  0.001801737
p_wrong:  0.008080777
Data Source:  BioPlex
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.989286331
p_ni:  0.010713662
p_wrong:  7e-9
Data Source:  BioPlex
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
p_int:  0.985279493
p_ni:  0.014681253
p_wrong:  0.000039253
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.977002144
p_ni:  0.006892673
p_wrong:  0.016105183
Data Source:  BioPlex
AACS
Tbio
Family:  Enzyme
Novelty:  0.01297361
p_int:  0.970275002
p_ni:  6.1e-8
p_wrong:  0.029724937
Data Source:  BioPlex
Pathways (61)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
62.1
lifestyle measurement
1
1
1
46.9
lymphocyte count
2
1
2
46.5
lymphocyte percentage of leukocytes
1
1
1
46.1
neutrophil percentage of leukocytes
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
62.1
lifestyle measurement
1
46.9
lymphocyte count
2
46.5
lymphocyte percentage of leukocytes
1
46.1
neutrophil percentage of leukocytes
1
31.4
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 1
VGNC:9144
741106
Macaque
calcium voltage-gated channel auxiliary subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:1405]
Mouse
MGI:1206582
12299
Rat
RGD:2249
29658
Dog
calcium voltage-gated channel auxiliary subunit gamma 1
VGNC:38647
610892
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 1
Macaque
calcium voltage-gated channel auxiliary subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:1405]
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit gamma 1
Publication Statistics
PubMed Score 8.25
PubMed score by year
PubTator Score 5.11
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title