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Tbio
MEF2C
Myocyte-specific enhancer factor 2C

Protein Summary
Description
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isofor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340208
  • ENSP00000340874
  • ENSG00000081189
  • ENST00000424173
  • ENSP00000389610
  • ENST00000437473
  • ENSP00000396219
  • ENST00000504921
  • ENSP00000421925
  • ENST00000508569
  • ENSP00000423597
  • ENST00000514015
  • ENSP00000424606
  • ENST00000514028
  • ENSP00000426665
  • ENST00000625674
  • ENSP00000487430
  • ENST00000628656
  • ENSP00000487311
  • ENST00000629612
  • ENSP00000486554
  • ENST00000636294
  • ENSP00000490473
  • ENST00000636998
  • ENSP00000490630
  • ENST00000637732
  • ENSP00000490241

Symbol
  • DEL5q14.3
  • C5DELq14.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
kinase
0.93
transcription factor perturbation
0.91
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 536.13   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 1196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 536.13   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 1196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 109
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0