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Tbio
MEF2C
Myocyte-specific enhancer factor 2C

Protein Summary
Description
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isofor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340208
  • ENSP00000340874
  • ENSG00000081189
  • ENST00000424173
  • ENSP00000389610
  • ENST00000437473
  • ENSP00000396219
  • ENST00000504921
  • ENSP00000421925
  • ENST00000508569
  • ENSP00000423597
  • ENST00000514015
  • ENSP00000424606
  • ENST00000514028
  • ENSP00000426665
  • ENST00000625674
  • ENSP00000487430
  • ENST00000628656
  • ENSP00000487311
  • ENST00000629612
  • ENSP00000486554
  • ENST00000636294
  • ENSP00000490473
  • ENST00000636998
  • ENSP00000490630
  • ENST00000637732
  • ENSP00000490241

Symbol
  • DEL5q14.3
  • C5DELq14.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
kinase
0.93
transcription factor perturbation
0.91
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.59   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 1196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.59   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 1196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 109
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
5
4
7.1
99.5
mathematical ability
4
3
4
98
intelligence
6
9
5
5.8
97.5
mean platelet volume
4
2
4
94.1
platelet count
3
2
2
2.7
91.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
7.1
99.5
mathematical ability
4
98
intelligence
5
5.8
97.5
mean platelet volume
4
94.1
platelet count
2
2.7
91.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myocyte enhancer factor 2C
VGNC:4086
461760
Macaque
myocyte enhancer factor 2C
694992
Mouse
MGI:99458
17260
Rat
RGD:1563119
499497
Dog
myocyte enhancer factor 2C
VGNC:43144
479155
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myocyte enhancer factor 2C
Macaque
myocyte enhancer factor 2C
Mouse
Rat
Dog
myocyte enhancer factor 2C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q06413-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (77)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
ERK/MAPK targets
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Circadian Clock
Cytokine Signaling in Immune system
Developmental Biology
ERK/MAPK targets
Gene expression (Transcription)
Gene Ontology Terms (119)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (256)
1 – 10 of 256
MEF2B
Tbio
Family: TF
Novelty: 0.03094093
p_int: 0.999997108
p_wrong: 0.000002891
Data Source: BioPlex
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.993
Data Source: STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.991
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.988
Data Source: STRINGDB
MYOG
Tbio
Family: TF
Novelty: 0.00074867
Score: 0.988
Data Source: Reactome,STRINGDB
MYOD1
Tbio
Family: TF
Novelty: 0.00053412
Score: 0.987
Data Source: Reactome,STRINGDB
MAPK7
Tchem
Family: Kinase
Novelty: 0.00257226
Score: 0.987
Data Source: Reactome,STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.98
Data Source: STRINGDB
HAND2
Tbio
Family: TF
Novelty: 0.00478924
Score: 0.98
Data Source: STRINGDB
HDAC4
Tclin
Family: Epigenetic
Novelty: 0.00217749
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  416.59

PubMed score by year
PubTator Score  179.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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