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Tbio
AOX1
Aldehyde oxidase

Protein Summary
Description
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374700
  • ENSP00000363832
  • ENSG00000138356

Symbol
  • AO
  • AO
  • AOH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
disease perturbation
0.95
PubMedID
0.82
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.84   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.84   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamins B6 activation to pyridoxal phosphate
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamins B6 activation to pyridoxal phosphate
Gene Ontology Terms (19)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (136)
1 – 10 of 136
CYP2A6
Tchem
Novelty: 0.00105285
Score: 0.954
Data Source: STRINGDB
NNMT
Tchem
Family: Enzyme
Novelty: 0.00602892
Score: 0.954
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.95
Data Source: STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.948
Data Source: STRINGDB
AGXT2
Tbio
Family: Enzyme
Novelty: 0.02018289
Score: 0.943
Data Source: STRINGDB
SUOX
Tbio
Family: Enzyme
Novelty: 0.00971136
Score: 0.941
Data Source: STRINGDB
ADH5
Tchem
Family: Enzyme
Novelty: 0.00248968
Score: 0.94
Data Source: STRINGDB
ADH1B
Tclin
Family: Enzyme
Novelty: 0.00204308
Score: 0.938
Data Source: STRINGDB
MAOA
Tclin
Family: Enzyme
Novelty: 0.00031037
Score: 0.937
Data Source: STRINGDB
MAOB
Tclin
Family: Enzyme
Novelty: 0.00030366
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  357.84

PubMed score by year
PubTator Score  322.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer