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Tchem
GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Protein Summary
Description
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357308
  • ENSP00000349860
  • ENSG00000198380
  • ENST00000361060
  • ENSP00000354347

Symbol
  • GFAT
  • GFPT
  • GFA
  • GFAT
  • GFPT
  • MSLG
  • CMS12
  • GFAT1
  • CMSTA1
  • GFAT 1
  • GFAT1m
  • GFPT1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological process
0.98
interacting protein
0.93
kinase perturbation
0.93
ligand (protein) perturbation
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.68   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.68   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (118)
GFPT2
Tbio
Family:  Enzyme
Novelty:  0.01049877
p_int:  0.99998585
p_ni:  0.00001415
Score:  0.966
Data Source:  BioPlex,STRINGDB
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.853075636
p_ni:  0.146924364
Score:  0.595
Data Source:  BioPlex,STRINGDB
GNPNAT1
Tbio
Family:  Enzyme
Novelty:  0.01739665
Score:  0.981
Data Source:  STRINGDB
CAD
Tchem
Novelty:  0.00651422
Score:  0.968
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.964
Data Source:  STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.962
Data Source:  STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.955
Data Source:  STRINGDB
GLUL
Tchem
Family:  Enzyme
Novelty:  0.00086054
Score:  0.952
Data Source:  STRINGDB
PPAT
Tclin
Family:  Enzyme
Novelty:  0.01549862
Score:  0.938
Data Source:  STRINGDB
HK2
Tchem
Family:  Kinase
Novelty:  0.00144136
Score:  0.937
Data Source:  STRINGDB
Pathways (24)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective GFPT1 causes CMSTA1
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective GFPT1 causes CMSTA1
Disease
Diseases associated with glycosylation precursor biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
37.6
dentures
2
1
2
37.6
body mass index
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
37.6
dentures
2
37.6
body mass index
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamine--fructose-6-phosphate transaminase 1
VGNC:270
450203
Macaque
glutamine--fructose-6-phosphate transaminase 1
574376
Mouse
MGI:95698
14583
Rat
RGD:1549703
297417
Dog
glutamine--fructose-6-phosphate transaminase 1
VGNC:41187
474624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamine--fructose-6-phosphate transaminase 1
Macaque
glutamine--fructose-6-phosphate transaminase 1
Mouse
Rat
Dog
glutamine--fructose-6-phosphate transaminase 1
Publication Statistics
PubMed Score 268.68
PubMed score by year
PubTator Score 158.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title