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Tclin
PPAT
Amidophosphoribosyltransferase

Protein Summary
Description
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264220
  • ENSP00000264220
  • ENSG00000128059

Symbol
  • GPAT
  • GPAT
  • PRAT
  • ATASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
transcription factor perturbation
0.88
protein domain
0.85
histone modification site profile
0.78
microRNA
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.79   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.79   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
mercaptopurine
chemical structure image
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoribosyl pyrophosphate amidotransferase
VGNC:667
461309
Macaque
phosphoribosyl pyrophosphate amidotransferase
694868
Mouse
MGI:2387203
231327
Rat
RGD:620237
117544
Dog
phosphoribosyl pyrophosphate amidotransferase
VGNC:44839
611407
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoribosyl pyrophosphate amidotransferase
Macaque
phosphoribosyl pyrophosphate amidotransferase
Mouse
Rat
Dog
phosphoribosyl pyrophosphate amidotransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q06203-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (60)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Protein-Protein Interactions (140)
1 – 10 of 140
NUDT5
Tbio
Family: Enzyme
Novelty: 0.02550535
p_int: 0.929562764
p_ni: 0.070437236
Score: 0.555
Data Source: BioPlex,STRINGDB
B2M
Tbio
Novelty: 0.00011248
p_int: 0.836337857
p_ni: 0.163662143
Score: 0.209
Data Source: BioPlex,STRINGDB
GART
Tclin
Novelty: 0.00524985
Score: 0.999
Data Source: STRINGDB
PAICS
Tbio
Novelty: 0.00215277
Score: 0.996
Data Source: STRINGDB
PFAS
Tbio
Family: Enzyme
Novelty: 0.00252212
Score: 0.994
Data Source: STRINGDB
PRPS1
Tbio
Family: Kinase
Novelty: 0.01139656
Score: 0.987
Data Source: STRINGDB
PRPS2
Tbio
Family: Kinase
Novelty: 0.02472415
Score: 0.987
Data Source: STRINGDB
GLUL
Tchem
Family: Enzyme
Novelty: 0.00086054
Score: 0.976
Data Source: STRINGDB
CAD
Tchem
Novelty: 0.00651422
Score: 0.976
Data Source: STRINGDB
ATIC
Tchem
Novelty: 0.00466845
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  61.79

PubMed score by year
PubTator Score  67.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer