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Tbio
REG3A
Regenerating islet-derived protein 3-alpha

Protein Summary
Description
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305165
  • ENSP00000304311
  • ENSG00000172016
  • ENST00000393878
  • ENSP00000377456
  • ENST00000409839
  • ENSP00000386630

Symbol
  • HIP
  • PAP
  • PAP1
  • HIP
  • PAP
  • PAP1
  • REG3
  • INGAP
  • PAP-H
  • PBCGF
  • HIP/PAP
  • REG-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.57
tissue
0.56
biological term
0.51
biological process
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.04   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 455   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.04   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
52
smoking status measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
52
smoking status measurement
1
33.1
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regenerating family member 3 alpha
VGNC:6402
459349
Dog
regenerating islet-derived 3 alpha
403411
Horse
regenerating islet-derived protein 3-gamma-like
100068275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regenerating family member 3 alpha
Dog
regenerating islet-derived 3 alpha
Horse
regenerating islet-derived protein 3-gamma-like
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q06141-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (34)
1 – 10 of 34
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.988825278
p_ni:  0.011174722
Score:  0.281
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.986026426
p_ni:  0.013973574
Score:  0.412
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.973821136
p_ni:  0.026178864
Score:  0.153
Data Source:  BioPlex,STRINGDB
REG3G
Tbio
Novelty:  0.01996388
Score:  0.932
Data Source:  STRINGDB
PRSS2
Tchem
Family:  Enzyme
Novelty:  0.00959404
Score:  0.925
Data Source:  STRINGDB
PRSS3P2
Tdark
Family:  Enzyme
Novelty:  0.00959404
Score:  0.925
Data Source:  STRINGDB
PRSS3
Tchem
Family:  Enzyme
Novelty:  0.00360444
Score:  0.904
Data Source:  STRINGDB
REG1A
Tbio
Novelty:  0.00492251
Score:  0.866
Data Source:  STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
Score:  0.758
Data Source:  STRINGDB
DEFA6
Tbio
Novelty:  0.0363171
Score:  0.71
Data Source:  STRINGDB
Publication Statistics
PubMed Score  334.04

PubMed score by year
PubTator Score  1423.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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