Tchem PTPN11 Tyrosine-protein phosphatase non-receptor type 11

Protein Summary

Description

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q06124
• A8K1D9
• Q96HD7

Gene Name

• PTPN11

Ensembl ID

• ENST00000351677
• ENSP00000340944
• ENSG00000179295
• ENST00000392597
• ENSP00000376376
• ENST00000635625
• ENSP00000489597

Symbol

• PTP2C
• SHPTP2
• CFC
• NS1
• JMML
• SHP2
• BPTP3
• PTP2C
• METCDS
• PTP-1D
• SH-PTP2
• SH-PTP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
virus perturbation	1
biological term	0.99
interacting protein	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1708.79   (req: < 5)

Gene RIFs: 501   (req: <= 3)

Antibodies: 1322   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1708.79   (req: >= 5)

Gene RIFs: 501   (req: > 3)

Antibodies: 1322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 74

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 152

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0