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Tbio
TNP2
Nuclear transition protein 2

Protein Summary
Description
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312693
  • ENSP00000325738
  • ENSG00000178279

Symbol
  • TP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
cellular component
0.56
phenotype
0.52
tissue
0.5
cell line
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.13   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.13   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (75)
1 – 10 of 75
TNP1
Tbio
Novelty: 0.01264731
Score: 0.972
Data Source: STRINGDB
PRM2
Tbio
Novelty: 0.0050028
Score: 0.912
Data Source: STRINGDB
PRM3
Tdark
Novelty: 0.03634194
Score: 0.839
Data Source: STRINGDB
PRM1
Tbio
Novelty: 0.009665
Score: 0.803
Data Source: STRINGDB
KPNA3
Tbio
Novelty: 0.02173035
Score: 0.8
Data Source: STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
Score: 0.781
Data Source: STRINGDB
HIST3H3
Tbio
Novelty: 0.04915012
Score: 0.757
Data Source: STRINGDB
MPHOSPH8
Tbio
Family: Epigenetic
Novelty: 0.0534439
Score: 0.729
Data Source: STRINGDB
CENPA
Tbio
Novelty: 0.00154245
Score: 0.727
Data Source: STRINGDB
H2AFB1
Tbio
Novelty: 0.08770329
Score: 0.723
Data Source: STRINGDB
Publication Statistics
PubMed Score  82.13

PubMed score by year
PubTator Score  156.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer