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Tclin
SLC18A2
Synaptic vesicular amine transporter

Protein Summary
Description
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473). Requisite for vesicular amine storage prior to secretion via exocytosis. This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298472
  • ENSP00000298472
  • ENSG00000165646
  • ENST00000644641
  • ENSP00000496339

Symbol
  • SVMT
  • VMAT2
  • SVAT
  • SVMT
  • VAT2
  • VMAT2
  • PKDYS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.89
biological process
0.85
kinase perturbation
0.81
molecular function
0.79
chemical
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1585.04   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1585.04   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (10)
ketanserin
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dexamfetamine
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reserpine
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lisdexamfetamine
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benzphetamine
Rendered image for benzphetamine
valbenazine
Rendered image for valbenazine
deserpidine
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rescinnamine
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tetrabenazine
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deutetrabenazine
Rendered image for deutetrabenazine
Active Ligands (17)
tetrabenazine
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Dihydrotetrabenazine
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CHEMBL4214975
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[<sup>125</sup>I]iodovinyl-TBZ
no chemical structure image available
CHEMBL4205254
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CHEMBL4207658
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CHEMBL4202787
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CHEMBL213814
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CHEMBL4207838
Rendered image for CHEMBL4207838
Protein-Protein Interactions (122)
SLC6A3
Tclin
Family:  Transporter
Novelty:  0.00017601
Score:  0.954
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.943
Data Source:  STRINGDB
SLC32A1
Tchem
Family:  Transporter
Novelty:  0.00237273
Score:  0.942
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.94
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.938
Data Source:  STRINGDB
SYN1
Tbio
Novelty:  0.00093242
Score:  0.937
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.931
Data Source:  STRINGDB
SYN3
Tbio
Novelty:  0.0065245
Score:  0.929
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.923
Data Source:  STRINGDB
SYN2
Tbio
Novelty:  0.00574709
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Dopamine Neurotransmitter Release Cycle (R-HSA-212676)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Norepinephrine Neurotransmitter Release Cycle
Name
Explore in Pharos
Explore in Source
Dopamine Neurotransmitter Release Cycle
Na+/Cl- dependent neurotransmitter transporters
Neuronal System
Neurotransmitter release cycle
Norepinephrine Neurotransmitter Release Cycle
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 18 member A2
VGNC:7861
466213
Macaque
solute carrier family 18 member A2
701133
Mouse
MGI:106677
214084
Rat
RGD:3694
25549
Dog
solute carrier family 18 member A2
VGNC:46256
486908
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 18 member A2
Macaque
solute carrier family 18 member A2
Mouse
Rat
Dog
solute carrier family 18 member A2
Publication Statistics
PubMed Score 1585.04
PubMed score by year
PubTator Score 353.88
PubTator score by year
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Related Publications
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PMID
Year
Title