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Tchem
CHRNB3
Neuronal acetylcholine receptor subunit beta-3

Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289957
  • ENSP00000289957
  • ENSG00000147432
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
tissue
0.64
cell line
0.62
cell type or tissue
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.85   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.85   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
TYRO3
Tchem
Family:  Kinase
Novelty:  0.00233016
p_int:  0.999999978
p_ni:  2.1e-8
Score:  0.569
Data Source:  BioPlex,STRINGDB
LEMD2
Tbio
Novelty:  0.12460123
p_int:  0.979008265
p_ni:  0.020991735
Score:  0.224
Data Source:  BioPlex,STRINGDB
CHRNA7
Tchem
Family:  IC
Novelty:  0.00590784
Score:  0.922
Data Source:  STRINGDB
CHRNA6
Tchem
Family:  IC
Novelty:  0.03991261
Score:  0.914
Data Source:  Reactome,STRINGDB
CHRNB2
Tclin
Family:  IC
Novelty:  0.01251655
Score:  0.911
Data Source:  STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.91
Data Source:  Reactome,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
Score:  0.909
Data Source:  STRINGDB
CHRNA2
Tchem
Family:  IC
Novelty:  0.02542208
Score:  0.908
Data Source:  Reactome,STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
Score:  0.908
Data Source:  Reactome,STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
3
3
3
91.7
1
1
1
33.1
tobacco smoke exposure measurement
1
1
1
21.5
red blood cell distribution width
1
1
1
12.9
smoking cessation
2
1
2
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
3
91.7
1
33.1
tobacco smoke exposure measurement
1
21.5
red blood cell distribution width
1
12.9
smoking cessation
2
12.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic beta 3 subunit
VGNC:7590
464500
Mouse
MGI:106212
108043
Rat
RGD:621544
171131
Dog
cholinergic receptor nicotinic beta 3 subunit
VGNC:39244
482837
Horse
cholinergic receptor nicotinic beta 3 subunit
VGNC:16528
100054095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic beta 3 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic beta 3 subunit
Horse
cholinergic receptor nicotinic beta 3 subunit
Publication Statistics
PubMed Score 33.85
PubMed score by year
PubTator Score 21.42
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title