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Tchem
RNASEL
2-5A-dependent ribonuclease

Protein Summary
Description
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367559
  • ENSP00000356530
  • ENSG00000135828
  • ENST00000539397
  • ENSP00000440844

Symbol
  • RNS4
  • RNS4
  • PRCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
transcription factor perturbation
0.84
biological term
0.75
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 632.32   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 632.32   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
2
95.3
circadian rhythm
3
2
1
1.3
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
95.3
circadian rhythm
1
1.3
91.9
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (86)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Gene Ontology Terms (21)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (235)
1 – 10 of 235
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.99999908
p_ni: 9.2e-7
Score: 0.27
Data Source: BioPlex,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.998217819
p_ni: 0.001781793
p_wrong: 3.88e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.997226322
p_ni: 0.002773265
p_wrong: 4.13e-7
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.959569357
p_ni: 0.017586917
p_wrong: 0.022843726
Score: 0.156
Data Source: BioPlex,STRINGDB
HSD17B1
Tchem
Family: Enzyme
Novelty: 0.00313425
p_int: 0.952880216
p_ni: 0.046870586
p_wrong: 0.000249198
Data Source: BioPlex
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.939908361
p_ni: 0.060058405
p_wrong: 0.000033234
Score: 0.243
Data Source: BioPlex,STRINGDB
LPAR4
Tchem
Family: GPCR
Novelty: 0.02200758
p_int: 0.925509705
p_ni: 0.074489295
p_wrong: 0.000001
Data Source: BioPlex
SLC37A3
Tdark
Family: Transporter
Novelty: 0.21571546
p_int: 0.898579831
p_ni: 0.072335545
p_wrong: 0.029084624
Score: 0.268
Data Source: BioPlex,STRINGDB
SYP
Tbio
Novelty: 0.00021543
p_int: 0.769562694
p_ni: 0.22998933
p_wrong: 0.000447976
Score: 0.176
Data Source: BioPlex,STRINGDB
ABCE1
Tbio
Family: Transporter
Novelty: 0.00529126
Score: 0.983
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  632.32

PubMed score by year
PubTator Score  401.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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