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Tchem
RNASEL
2-5A-dependent ribonuclease

Protein Summary
Description
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367559
  • ENSP00000356530
  • ENSG00000135828
  • ENST00000539397
  • ENSP00000440844

Symbol
  • RNS4
  • RNS4
  • PRCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
transcription factor perturbation
0.84
biological term
0.75
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 682.3   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 682.3   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (20)
p3A2' p5' A2' p5'A
Rendered image for p3A2' p5' A2' p5'A
Oligoadenylate analogue
Rendered image for Oligoadenylate analogue
Oligoadenylate analogue
Rendered image for Oligoadenylate analogue
Oligoadenylate analogue
Rendered image for Oligoadenylate analogue
CHEMBL3817920
Rendered image for CHEMBL3817920
Oligoadenylate analogue
Rendered image for Oligoadenylate analogue
Oligoadenylate analogue
Rendered image for Oligoadenylate analogue
CHEMBL601938
Rendered image for CHEMBL601938
CHEMBL3818262
Rendered image for CHEMBL3818262
CHEMBL591446
Rendered image for CHEMBL591446
Protein-Protein Interactions (235)
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.99999908
p_ni:  9.2e-7
Score:  0.27
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.998217819
p_ni:  0.001781793
p_wrong:  3.88e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.997226322
p_ni:  0.002773265
p_wrong:  4.13e-7
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.959569357
p_ni:  0.017586917
p_wrong:  0.022843726
Score:  0.156
Data Source:  BioPlex,STRINGDB
HSD17B1
Tchem
Family:  Enzyme
Novelty:  0.00313425
p_int:  0.952880216
p_ni:  0.046870586
p_wrong:  0.000249198
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.939908361
p_ni:  0.060058405
p_wrong:  0.000033234
Score:  0.243
Data Source:  BioPlex,STRINGDB
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.925509705
p_ni:  0.074489295
p_wrong:  0.000001
Data Source:  BioPlex
SLC37A3
Tdark
Family:  Transporter
Novelty:  0.21571546
p_int:  0.898579831
p_ni:  0.072335545
p_wrong:  0.029084624
Score:  0.268
Data Source:  BioPlex,STRINGDB
SYP
Tbio
Novelty:  0.00021543
p_int:  0.769562694
p_ni:  0.22998933
p_wrong:  0.000447976
Score:  0.176
Data Source:  BioPlex,STRINGDB
ABCE1
Tbio
Family:  Transporter
Novelty:  0.00529126
Score:  0.983
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (86)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
4
4
1.2
98.8
circadian rhythm
6
4
3
1.4
98.1
physical activity measurement
1
1
1
53.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
1.2
98.8
circadian rhythm
3
1.4
98.1
physical activity measurement
1
53.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease L
VGNC:6985
469607
Macaque
ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050]
Mouse
MGI:1098272
24014
Rat
RGD:727933
359726
Dog
ribonuclease L
VGNC:45615
490310
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease L
Macaque
ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050]
Mouse
Rat
Dog
ribonuclease L
Publication Statistics
PubMed Score 682.30
PubMed score by year
PubTator Score 401.17
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title