Tbio CALD1 Caldesmon

Protein Summary

Description

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q05682
• A8K0X1
• Q13978
• Q13979
• Q14741
• Q14742
• Q9UD91
• CDM

Gene Name

• CALD1

Ensembl ID

• ENST00000361675
• ENSP00000354826
• ENSG00000122786
• ENST00000361901
• ENSP00000354513
• ENST00000393118
• ENSP00000376826
• ENST00000417172
• ENSP00000398826
• ENST00000422748
• ENSP00000395710
• ENST00000424922
• ENSP00000393621

Symbol

• CAD
• CDM
• CDM
• HCAD
• LCAD
• H-CAD
• L-CAD
• NAG22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
ligand (protein) perturbation	0.99
PubMedID	0.99
small molecule perturbation	0.95
interacting protein	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1228.94   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 1173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1228.94   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 1173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0