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Tchem
EEF1A2
Elongation factor 1-alpha 2

Protein Summary
Description
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217182
  • ENSP00000217182
  • ENSG00000101210

Symbol
  • EEF1AL
  • STN
  • HS1
  • STN
  • EF1A
  • STNL
  • MRD38
  • EEF1AL
  • EIEE33
  • EF-1-alpha-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
molecular function
0.98
hub protein
0.97
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 656.76   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 656.76   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
26
31.9
1
1
0
1.1
0.5
1
1
0
1.1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
26
31.9
0
1.1
0.5
0
1.1
0.5
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Eukaryotic Translation Elongation (R-HSA-156842)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Eukaryotic Translation Elongation
Reactome
Metabolism of proteins
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Eukaryotic Translation Elongation
Metabolism of proteins
Translation
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (337)
1 – 10 of 337
EEF1A1
Tchem
Novelty: 0.00059953
p_int: 1
Score: 0.995
Data Source: BioPlex,STRINGDB
EEF1D
Tbio
Novelty: 0.02480745
p_int: 0.999999999
p_ni: 1e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
PBDC1
Tdark
Novelty: 0.79983498
p_int: 0.999999819
p_ni: 1.81e-7
Score: 0.73
Data Source: BioPlex,STRINGDB
EEF1G
Tbio
Novelty: 0.01473013
p_int: 0.999999201
p_ni: 7.99e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
EEF1AKMT1
Tdark
Family: Enzyme
Novelty: 0.22249584
p_int: 0.999997796
p_ni: 0.000002204
Score: 0.81
Data Source: BioPlex,STRINGDB
CARS
Tbio
Family: Enzyme
Novelty: 0.02078279
p_int: 0.99990079
p_ni: 0.00009921
Score: 0.894
Data Source: BioPlex,STRINGDB
ABTB1
Tbio
Novelty: 0.08918942
p_int: 0.999837981
p_ni: 0.000162019
Score: 0.751
Data Source: BioPlex,STRINGDB
NXPH2
Tdark
Novelty: 0.65790631
p_int: 0.999805808
p_ni: 0.000194192
Score: 0.152
Data Source: BioPlex,STRINGDB
VARS
Tchem
Family: Enzyme
Novelty: 0.00720227
p_int: 0.999584797
p_ni: 0.000415153
p_wrong: 5e-8
Score: 0.89
Data Source: BioPlex,STRINGDB
PSG1
Tbio
Novelty: 0.0239046
p_int: 0.998646134
p_ni: 0.001353866
Data Source: BioPlex
Publication Statistics
PubMed Score  656.76

PubMed score by year
PubTator Score  1192.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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