Tchem EEF1A2 Elongation factor 1-alpha 2

Protein Summary

Description

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q05639
• B5BUF3
• E1P5J1
• P54266
• Q0VGC7
• EF-1-alpha-2

Gene Name

• EEF1A2

Ensembl ID

• ENST00000217182
• ENSP00000217182
• ENSG00000101210

Symbol

• EEF1AL
• STN
• HS1
• STN
• EF1A
• STNL
• MRD38
• EEF1AL
• EIEE33
• EF-1-alpha-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein complex	1
molecular function	0.98
hub protein	0.97
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Elongation Factor 1-alpha 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Elongation Factor 1-alpha 2

Protein / Hydrolase / Elongation Factor 1-alpha 2

Protein / Enzyme Modulator / G-protein / Elongation Factor 1-alpha 2

DTO Classes

Protein / Enzyme / Hydrolase / Elongation Factor 1-alpha 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 835.87   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 835.87   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0