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Tclin
GRIN1
Glutamate receptor ionotropic, NMDA 1

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761). The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371546
  • ENSP00000360601
  • ENSG00000176884
  • ENST00000371550
  • ENSP00000360605
  • ENST00000371553
  • ENSP00000360608
  • ENST00000371559
  • ENSP00000360614
  • ENST00000371560
  • ENSP00000360615
  • ENST00000371561
  • ENSP00000360616

Symbol
  • NMDAR1
  • NR1
  • MRD8
  • GluN1
  • NMDA1
  • NDHMSD
  • NDHMSR
  • NMD-R1
  • NMDAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
biological term
0.88
chemical
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 881.1   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 1174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 881.1   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 1174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor NMDA type subunit 1
VGNC:53282
465176
Macaque
glutamate ionotropic receptor NMDA type subunit 1
574380
Mouse
MGI:95819
14810
Rat
RGD:2736
24408
Dog
glutamate ionotropic receptor NMDA type subunit 1
VGNC:41491
494007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor NMDA type subunit 1
Macaque
glutamate ionotropic receptor NMDA type subunit 1
Mouse
Rat
Dog
glutamate ionotropic receptor NMDA type subunit 1
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q05586-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (62)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Axon guidance
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Axon guidance
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
Gene Ontology Terms (75)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (362)
1 – 10 of 362
DLG4
Tchem
Novelty: 0.00057285
Score: 0.993
Data Source: Reactome,STRINGDB
GRIN2B
Tclin
Family: IC
Novelty: 0.00035058
Score: 0.991
Data Source: Reactome,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.99
Data Source: Reactome,STRINGDB
CAMK2G
Tchem
Family: Kinase
Novelty: 0.04642387
Score: 0.98
Data Source: Reactome,STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.00534906
Score: 0.979
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.977
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.977
Data Source: Reactome,STRINGDB
GRIN2D
Tclin
Family: IC
Novelty: 0.00457474
Score: 0.975
Data Source: Reactome,STRINGDB
DLG2
Tbio
Novelty: 0.00999909
Score: 0.975
Data Source: Reactome,STRINGDB
GRIN2C
Tclin
Family: IC
Novelty: 0.00430771
Score: 0.972
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  881.10

PubMed score by year
PubTator Score  824.2

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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