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Tclin
GRIN1
Glutamate receptor ionotropic, NMDA 1

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761). The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371546
  • ENSP00000360601
  • ENSG00000176884
  • ENST00000371550
  • ENSP00000360605
  • ENST00000371553
  • ENSP00000360608
  • ENST00000371559
  • ENSP00000360614
  • ENST00000371560
  • ENSP00000360615
  • ENST00000371561
  • ENSP00000360616

Symbol
  • NMDAR1
  • NR1
  • MRD8
  • GluN1
  • NMDA1
  • NDHMSD
  • NDHMSR
  • NMD-R1
  • NMDAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
biological term
0.88
chemical
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 743.66   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 1174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 743.66   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 1174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (62)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Axon guidance
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Axon guidance
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
Gene Ontology Terms (75)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (362)
1 – 10 of 362
DLG4
Tchem
Novelty: 0.00079421
Score: 0.993
Data Source: Reactome,STRINGDB
GRIN2B
Tclin
Family: IC
Novelty: 0.00042857
Score: 0.991
Data Source: Reactome,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00075253
Score: 0.99
Data Source: Reactome,STRINGDB
CAMK2G
Tchem
Family: Kinase
Novelty: 0.08749205
Score: 0.98
Data Source: Reactome,STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.01196206
Score: 0.979
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.00904059
Score: 0.977
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00092113
Score: 0.977
Data Source: Reactome,STRINGDB
GRIN2D
Tclin
Family: IC
Novelty: 0.00730668
Score: 0.975
Data Source: Reactome,STRINGDB
DLG2
Tbio
Novelty: 0.01593948
Score: 0.975
Data Source: Reactome,STRINGDB
GRIN2C
Tclin
Family: IC
Novelty: 0.00588631
Score: 0.972
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  743.66

PubMed score by year
PubTator Score  824.2

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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