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Tchem
PRKCZ
Protein kinase C zeta type

Protein Summary
Description
Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378567
  • ENSP00000367830
  • ENSG00000067606
  • ENST00000400921
  • ENSP00000383712
  • ENST00000461106
  • ENSP00000426412

Symbol
  • PKC2
  • PKC2
  • PKC-ZETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
protein domain
1
molecular function
0.99
biological term
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.42   (req: < 5)
Gene RIFs: 166   (req: <= 3)
Antibodies: 774   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.42   (req: >= 5)
Gene RIFs: 166   (req: > 3)
Antibodies: 774   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0