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Tchem
LIPE
Hormone-sensitive lipase

Protein Summary
Description
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244289
  • ENSP00000244289
  • ENSG00000079435

Symbol
  • HSL
  • LHS
  • AOMS4
  • FPLD6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
kinase
0.85
gene perturbation
0.82
biological term
0.76
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.2   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 435   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.2   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 255
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
3
4
96.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
96.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipase E, hormone sensitive type
VGNC:7485
456076
Macaque
lipase E, hormone sensitive type
707997
Mouse
MGI:96790
16890
Rat
RGD:3010
25330
Dog
lipase E, hormone sensitive type
VGNC:42695
403607
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipase E, hormone sensitive type
Macaque
lipase E, hormone sensitive type
Mouse
Rat
Dog
lipase E, hormone sensitive type
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q05469-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (103)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride catabolism
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride catabolism
Triglyceride metabolism
Protein-Protein Interactions (206)
1 – 10 of 206
PNPLA2
Tchem
Family: Enzyme
Novelty: 0.00149181
Score: 0.996
Data Source: STRINGDB
PLIN1
Tbio
Novelty: 0.00200378
Score: 0.994
Data Source: STRINGDB
FABP4
Tchem
Novelty: 0.00107707
Score: 0.981
Data Source: Reactome,STRINGDB
PNPLA3
Tbio
Family: Enzyme
Novelty: 0.00180327
Score: 0.976
Data Source: STRINGDB
PNPLA4
Tbio
Family: Enzyme
Novelty: 0.07471752
Score: 0.972
Data Source: STRINGDB
LIPC
Tchem
Family: Enzyme
Novelty: 0.00219107
Score: 0.963
Data Source: STRINGDB
PNLIP
Tclin
Family: Enzyme
Novelty: 0.00043254
Score: 0.959
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.957
Data Source: Reactome,STRINGDB
LIPF
Tclin
Family: Enzyme
Novelty: 0.03073254
Score: 0.954
Data Source: STRINGDB
CEL
Tchem
Family: Enzyme
Novelty: 0.00156761
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  372.20

PubMed score by year
PubTator Score  367.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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