GAD2
Glutamate decarboxylase 2
Protein Classes
Protein Summary
Catalyzes the production of GABA. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
- ENST00000259271
- ENSP00000259271
- ENSG00000136750
- ENST00000376261
- ENSP00000365437
- GAD65
- GAD65
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phosphatase | 0.98 | ||
trait | 0.93 | ||
cellular component | 0.92 | ||
disease | 0.85 | ||
molecular function | 0.73 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1774.3 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 650 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1774.3 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 650 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
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1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glucose measurement | 1 | 1 | 1 | 59.6 | |||||
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glucose measurement | 1 | 59.6 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutamate decarboxylase 2 | VGNC:12337 | 466026 | |||||
Macaque | glutamate decarboxylase 2 | 613029 | ||||||
Mouse | MGI:95634 | 14417 | ||||||
Rat | RGD:2653 | 24380 | ||||||
Dog | glutamate decarboxylase 2 | VGNC:41068 | 487107 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutamate decarboxylase 2 | |||||
Macaque | glutamate decarboxylase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamate decarboxylase 2 | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (27)
Reactome (10)
KEGG (7)
PathwayCommons (6)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | GABA synthesis | ||||
Reactome | GABA synthesis, release, reuptake and degradation | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | MECP2 regulates transcription of genes involved in GABA signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GABA synthesis | ||||
GABA synthesis, release, reuptake and degradation | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
MECP2 regulates transcription of genes involved in GABA signaling | ||||
Gene Ontology Terms (19)
Functions (4)
Components (11)
Processes (4)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (280)
1 – 10 of 280
SLC32A1
Family: Transporter
Novelty: 0.00237273
Score: 0.994
Data Source: STRINGDB
ABAT
Family: Enzyme
Novelty: 0.0078359
Score: 0.982
Data Source: STRINGDB
SNAP25
Novelty: 0.00148905
Score: 0.967
Data Source: STRINGDB
SYT1
Novelty: 0.00176103
Score: 0.957
Data Source: STRINGDB
GAD1
Family: Enzyme
Novelty: 0.00067443
Score: 0.956
Data Source: Reactome,STRINGDB
PTPRN
Family: Enzyme
Novelty: 0.00076479
Score: 0.949
Data Source: STRINGDB
GLUL
Family: Enzyme
Novelty: 0.00086054
Score: 0.949
Data Source: STRINGDB
VAMP2
Novelty: 0.00187736
Score: 0.947
Data Source: STRINGDB
STX1A
Novelty: 0.00087207
Score: 0.943
Data Source: STRINGDB
GLS2
Family: Enzyme
Novelty: 0.00284878
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score 1774.30
PubMed score by year
PubTator Score 842.88
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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