GAD2
Glutamate decarboxylase 2
Protein Summary
Catalyzes the production of GABA. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
- ENST00000259271
- ENSP00000259271
- ENSG00000136750
- ENST00000376261
- ENSP00000365437
- GAD65
- GAD65
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phosphatase | 0.98 | ||
trait | 0.93 | ||
cellular component | 0.92 | ||
disease | 0.85 | ||
molecular function | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2433.96 (req: < 5)
Gene RIFs: 93 (req: <= 3)
Antibodies: 650 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2433.96 (req: >= 5)
Gene RIFs: 93 (req: > 3)
Antibodies: 650 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0