Tbio GAD2 Glutamate decarboxylase 2

Protein Classes

PANTHER Classes

Protein / Lyase / Decarboxylase / Glutamate Decarboxylase 2

DTO Classes

Protein / Enzyme / Lyase / Decarboxylase / Glutamate Decarboxylase 2

Protein Summary

Description

Catalyzes the production of GABA. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q05329
• Q9UD87

Gene Name

• GAD2

Ensembl ID

• ENST00000259271
• ENSP00000259271
• ENSG00000136750
• ENST00000376261
• ENSP00000365437

Symbol

• GAD65
• GAD65

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phosphatase	0.98
trait	0.93
cellular component	0.92
disease	0.85
molecular function	0.73

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1120.68   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 650   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1120.68   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (27)

Reactome (10)

KEGG (7)

PathwayCommons (6)

WikiPathways (4)

GABA synthesis (R-HSA-888568)

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Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	GABA synthesis	2 targets	R-HSA-888568
Reactome	GABA synthesis, release, reuptake and degradation	19 targets	R-HSA-888590
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	MECP2 regulates transcription of genes involved in GABA signaling	3 targets	R-HSA-9022927

Name	Explore in Pharos	Explore in Source
GABA synthesis	2 targets	R-HSA-888568
GABA synthesis, release, reuptake and degradation	19 targets	R-HSA-888590
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
MECP2 regulates transcription of genes involved in GABA signaling	3 targets	R-HSA-9022927

Gene Ontology Terms (19)

Functions (4)

Components (11)

Processes (4)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
glutamate decarboxylase activity	Traceable Author Statement (TAS)	Reactome
glutamate binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
pyridoxal phosphate binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (280)

Explore Interacting Targets

1 – 10 of 280

• See Interactions on String-DB

SLC32A1

Tchem

Family: Transporter

Novelty: 0.00247724

Score: 0.994

Data Source: STRINGDB

ABAT

Tclin

Family: Enzyme

Novelty: 0.00944717

Score: 0.982

Data Source: STRINGDB

SNAP25

Tclin

Novelty: 0.0020914

Score: 0.967

Data Source: STRINGDB

SYT1

Tbio

Novelty: 0.00202951

Score: 0.957

Data Source: STRINGDB

GAD1

Tbio

Family: Enzyme

Novelty: 0.00102125

Score: 0.956

Data Source: Reactome,STRINGDB

PTPRN

Tbio

Family: Enzyme

Novelty: 0.00120688

Score: 0.949

Data Source: STRINGDB

GLUL

Tchem

Family: Enzyme

Novelty: 0.00112575

Score: 0.949

Data Source: STRINGDB

VAMP2

Tbio

Novelty: 0.00274235

Score: 0.947

Data Source: STRINGDB

STX1A

Tbio

Novelty: 0.00128938

Score: 0.943

Data Source: STRINGDB

GLS2

Tbio

Family: Enzyme

Novelty: 0.00145737

Score: 0.937

Data Source: STRINGDB

Publication Statistics

PubMed Score  1120.68

PubMed score by year

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PubTator Score  842.88

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARK

1-70

AACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNE

70-140

LLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIA

140-210

PVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEH

210-280

SHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAV

280-350

ADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ

350-420

MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREG

420-490

YEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMV

490-560

ISNPAATHQDIDFLIEEIERLGQDL

560-585

MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL

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Uniprot Keyword

3D-structure
Cell junction
Cell membrane
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Decarboxylase
Golgi apparatus
Lipoprotein
Lyase