GAD2
Glutamate decarboxylase 2
Protein Summary
Catalyzes the production of GABA. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
- ENST00000259271
- ENSP00000259271
- ENSG00000136750
- ENST00000376261
- ENSP00000365437
- GAD65
- GAD65
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phosphatase | 0.98 | ||
trait | 0.93 | ||
cellular component | 0.92 | ||
disease | 0.85 | ||
molecular function | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1774.3 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 650 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1774.3 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 650 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (280)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (27)
Reactome (10)
KEGG (7)
PathwayCommons (6)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | GABA synthesis | ||||
Reactome | GABA synthesis, release, reuptake and degradation | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | MECP2 regulates transcription of genes involved in GABA signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GABA synthesis | ||||
GABA synthesis, release, reuptake and degradation | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
MECP2 regulates transcription of genes involved in GABA signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (4)
Components (11)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glucose measurement | 1 | 1 | 1 | 59.6 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glucose measurement | 1 | 59.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutamate decarboxylase 2 | VGNC:12337 | 466026 | |||||
Macaque | glutamate decarboxylase 2 | 613029 | ||||||
Mouse | MGI:95634 | 14417 | ||||||
Rat | RGD:2653 | 24380 | ||||||
Dog | glutamate decarboxylase 2 | VGNC:41068 | 487107 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutamate decarboxylase 2 | |||||
Macaque | glutamate decarboxylase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamate decarboxylase 2 | |||||
Publication Statistics
PubMed Score 1774.30
PubMed score by year
PubTator Score 842.88
PubTator score by year
Related Publications
Text Mined References (109)
GeneRif Annotations (84)
Items per page:
0 of 0
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