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Tbio
CLC
Galectin-10

Protein Summary
Description
Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221804
  • ENSP00000221804
  • ENSG00000105205

Symbol
  • LGALS10
  • LGALS10A
  • GAL10
  • Gal-10
  • LGALS10
  • LGALS10A
  • LPPL_HUMAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.76
molecular function
0.6
cell type or tissue
0.58
cell line
0.56
gene perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.8   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.8   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
91.9
eosinophil percentage of leukocytes
1
1
1
63
eosinophil percentage of granulocytes
1
1
1
62.3
neutrophil percentage of granulocytes
1
1
1
59
basophil count
1
1
1
53.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
91.9
eosinophil percentage of leukocytes
1
63
eosinophil percentage of granulocytes
1
62.3
neutrophil percentage of granulocytes
1
59
basophil count
1
53.6
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (18)
1 – 10 of 18
GALE
Tchem
Family: Enzyme
Novelty: 0.00256798
Score: 0.808
Data Source: STRINGDB
RNASE2
Tchem
Family: Enzyme
Novelty: 0.00267471
Score: 0.671
Data Source: STRINGDB
CHD7
Tbio
Family: Epigenetic
Novelty: 0.00065444
Score: 0.652
Data Source: STRINGDB
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00059878
Score: 0.636
Data Source: STRINGDB
LGALS12
Tbio
Novelty: 0.05634386
Score: 0.604
Data Source: STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
Score: 0.579
Data Source: STRINGDB
PAICS
Tbio
Novelty: 0.00215277
Score: 0.57
Data Source: STRINGDB
EPX
Tbio
Family: Enzyme
Novelty: 0.00339273
Score: 0.566
Data Source: STRINGDB
ISYNA1
Tbio
Family: Enzyme
Novelty: 0.00302974
Score: 0.558
Data Source: STRINGDB
ADH1A
Tclin
Family: Enzyme
Novelty: 0.00199598
Score: 0.553
Data Source: STRINGDB
Publication Statistics
PubMed Score  205.80

PubMed score by year
PubTator Score  318.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer