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Tbio
EGR4
Early growth response protein 4

Protein Summary
Description
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000545030
  • ENSP00000445626
  • ENSG00000135625

Symbol
  • AT133
  • NGFIC
  • NGFI-C
  • PAT133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
PubMedID
0.69
biological process
0.63
histone modification site profile
0.57
transcription factor binding site profile
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.79   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.79   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
NFATC2
Tbio
Family:  TF
Novelty:  0.00312526
Score:  0.93
Data Source:  STRINGDB
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
Score:  0.901
Data Source:  STRINGDB
NFATC3
Tbio
Family:  TF
Novelty:  0.00602983
Score:  0.9
Data Source:  STRINGDB
NAB1
Tbio
Novelty:  0.03811946
Score:  0.776
Data Source:  STRINGDB
NAB2
Tbio
Novelty:  0.00860107
Score:  0.738
Data Source:  STRINGDB
NPAS4
Tbio
Family:  TF
Novelty:  0.00942626
Score:  0.698
Data Source:  STRINGDB
SLC12A5
Tchem
Family:  Transporter
Novelty:  0.0017288
Score:  0.697
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.574
Data Source:  STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
Score:  0.574
Data Source:  STRINGDB
NR4A1
Tchem
Family:  NR
Novelty:  0.00150135
Score:  0.559
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
PathwayCommons: pid
Downstream signaling in naïve CD8+ T cells
Name
Explore in Pharos
Explore in Source
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Downstream signaling in naïve CD8+ T cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
6
2
5.8
66.2
self reported educational attainment
1
1
1
42.3
puberty onset measurement
1
1
1
17.3
age at voice drop
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
5.8
66.2
self reported educational attainment
1
42.3
puberty onset measurement
1
17.3
age at voice drop
1
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
early growth response 4
VGNC:10638
740502
Mouse
MGI:99252
13656
Rat
RGD:2546
25129
Dog
early growth response 4
VGNC:40243
483112
Horse
early growth response 4 [Source:HGNC Symbol;Acc:HGNC:3241]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
early growth response 4
Mouse
Rat
Dog
early growth response 4
Horse
early growth response 4 [Source:HGNC Symbol;Acc:HGNC:3241]
Publication Statistics
PubMed Score 36.79
PubMed score by year
PubTator Score 20.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title