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Tchem
PTPN12
Tyrosine-protein phosphatase non-receptor type 12

Protein Summary
Description
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248594
  • ENSP00000248594
  • ENSG00000127947
  • ENST00000415482
  • ENSP00000392429
  • ENST00000435495
  • ENSP00000397991

Symbol
  • PTPG1
  • PTP-PEST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
transcription factor binding site profile
0.87
transcription factor
0.85
hub protein
0.79
PubMedID
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.59   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.59   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
9
9
92.9
waist-hip ratio
3
8
9
74.1
sex hormone-binding globulin measurement
2
1
2
71.9
eosinophil count
2
2
2
70.4
body height
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
92.9
waist-hip ratio
9
74.1
sex hormone-binding globulin measurement
2
71.9
eosinophil count
2
70.4
body height
1
57.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 12
VGNC:4484
463494
Macaque
protein tyrosine phosphatase, non-receptor type 12
721538
Mouse
MGI:104673
19248
Rat
RGD:620894
117255
Dog
protein tyrosine phosphatase, non-receptor type 12
VGNC:45169
483277
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 12
Macaque
protein tyrosine phosphatase, non-receptor type 12
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 12
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q05209-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Downregulation of ERBB2 signaling
Reactome
EGFR downregulation
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Downregulation of ERBB2 signaling
EGFR downregulation
Immune System
Interleukin-1 family signaling
Protein-Protein Interactions (120)
1 – 10 of 120
PSTPIP2
Tbio
Family:  Enzyme
Novelty:  0.05122819
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.952
Data Source:  BioPlex,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999999804
p_ni:  1.96e-7
Score:  0.844
Data Source:  BioPlex,STRINGDB
PXN
Tbio
Novelty:  0.00082031
p_int:  0.999999323
p_ni:  6.42e-7
p_wrong:  3.5e-8
Score:  0.862
Data Source:  BioPlex,STRINGDB
PTPN6
Tchem
Family:  Enzyme
Novelty:  0.00535749
p_int:  0.999965736
p_ni:  0.00003395
p_wrong:  3.15e-7
Score:  0.485
Data Source:  BioPlex,STRINGDB
SHC1
Tchem
Novelty:  0.00083615
p_int:  0.999950295
p_ni:  0.000049705
Score:  0.972
Data Source:  BioPlex,Reactome,STRINGDB
AIFM1
Tbio
Novelty:  0.00940088
p_int:  0.999265934
p_ni:  0.000734066
Score:  0.158
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.998357051
p_ni:  0.001642949
Data Source:  BioPlex
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.963
Data Source:  Reactome,STRINGDB
ERBB2
Tclin
Family:  Kinase
Novelty:  0.00003761
Score:  0.961
Data Source:  Reactome,STRINGDB
PSTPIP1
Tbio
Family:  Enzyme
Novelty:  0.0114281
Score:  0.947
Data Source:  STRINGDB
Publication Statistics
PubMed Score  84.59

PubMed score by year
PubTator Score  63.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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