Tbio MXD1 Max dimerization protein 1

Protein Summary

Description

Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q05195
• B2R6V8
• B7ZLI6
• D6W5G2
• Q6FI41
• Max dimerizer 1

Gene Name

• MXD1

Ensembl ID

• ENST00000264444
• ENSP00000264444
• ENSG00000059728
• ENST00000540449
• ENSP00000443935

Symbol

• MAD
• MAD
• MAD1
• BHLHC58

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
molecular function	0.9
transcription factor binding site profile	0.81
transcription factor perturbation	0.8
histone modification site profile	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Max Dimerization Protein 1

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Max Dimerization Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.79   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.79   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0