Tbio DNM1 Dynamin-1

Protein Summary

Description

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q05193
• A6NLM6
• Q5SYX0
• Q5SYX2
• Q6P3T6
• Q86VD2

Gene Name

• DNM1

Ensembl ID

• ENST00000341179
• ENSP00000345680
• ENSG00000106976
• ENST00000372923
• ENSP00000362014
• ENST00000393594
• ENSP00000377219
• ENST00000475805
• ENSP00000419225
• ENST00000486160
• ENSP00000420045
• ENST00000627543
• ENSP00000487310

Symbol

• DNM
• DNM
• EIEE31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
protein domain	1
molecular function	0.99
interacting protein	0.89
cellular component	0.74

Protein Classes

PANTHER Classes

Protein / Hydrolase / Dynamin-1

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-1

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Dynamin-1

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390.42   (req: < 5)

Gene RIFs: 64   (req: <= 3)

Antibodies: 609   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390.42   (req: >= 5)

Gene RIFs: 64   (req: > 3)

Antibodies: 609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0