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Tbio
DNM1
Dynamin-1

Protein Summary
Description
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341179
  • ENSP00000345680
  • ENSG00000106976
  • ENST00000372923
  • ENSP00000362014
  • ENST00000393594
  • ENSP00000377219
  • ENST00000475805
  • ENSP00000419225
  • ENST00000486160
  • ENSP00000420045
  • ENST00000627543
  • ENSP00000487310

Symbol
  • DNM
  • DNM
  • EIEE31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
molecular function
0.99
interacting protein
0.89
cellular component
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.51   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 609   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.51   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
65.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
65.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynamin 1
VGNC:4677
107976786
Macaque
dynamin 1
717697
Mouse
MGI:107384
13429
Rat
RGD:71096
140694
Dog
dynamin 1
VGNC:51945
491319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynamin 1
Macaque
dynamin 1
Mouse
Rat
Dog
dynamin 1
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q05193-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (48)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (374)
1 – 10 of 374
DNM2
Tchem
Novelty: 0.00265965
p_int: 0.999999766
p_ni: 2.34e-7
Score: 0.905
Data Source: BioPlex,STRINGDB
SNX9
Tbio
Novelty: 0.01737783
p_int: 0.999997121
p_ni: 0.000002879
Score: 0.99
Data Source: BioPlex,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.999994907
p_ni: 0.000005093
Score: 0.726
Data Source: BioPlex,STRINGDB
DNM3
Tbio
Novelty: 0.02365643
p_int: 0.999989332
p_ni: 0.000010668
Score: 0.976
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.982082942
p_ni: 0.017917058
Score: 0.176
Data Source: BioPlex,STRINGDB
TBC1D15
Tbio
Novelty: 0.11296513
p_int: 0.978167947
p_ni: 0.021832053
Score: 0.344
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.977807543
p_ni: 0.022192457
Data Source: BioPlex
LYPD6
Tbio
Novelty: 0.13867181
p_int: 0.975163287
p_ni: 0.024836713
Score: 0.41
Data Source: BioPlex,STRINGDB
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.951313794
p_ni: 0.048686206
Data Source: BioPlex
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.940399836
p_ni: 0.059600164
Data Source: BioPlex
Publication Statistics
PubMed Score  300.51

PubMed score by year
PubTator Score  146.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer