Tbio DNM1 Dynamin-1

Protein Summary

Description

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q05193
• A6NLM6
• Q5SYX0
• Q5SYX2
• Q6P3T6
• Q86VD2

Gene Name

• DNM1

Ensembl ID

• ENST00000341179
• ENSP00000345680
• ENSG00000106976
• ENST00000372923
• ENSP00000362014
• ENST00000393594
• ENSP00000377219
• ENST00000475805
• ENSP00000419225
• ENST00000486160
• ENSP00000420045
• ENST00000627543
• ENSP00000487310

Symbol

• DNM
• DNM
• EIEE31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
protein domain	1
molecular function	0.99
interacting protein	0.89
cellular component	0.74

Protein Classes

PANTHER Classes

Protein / Hydrolase / Dynamin-1

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-1

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Dynamin-1

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.14   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 609   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.14   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (374)

Explore Interacting Targets

1 – 10 of 374

• See Interactions on String-DB

DNM2

Tchem

Novelty:  0.00265965

p_int:  0.999999766

p_ni:  2.34e-7

Score:  0.905

Data Source:  BioPlex,STRINGDB

SNX9

Tbio

Novelty:  0.01737783

p_int:  0.999997121

p_ni:  0.000002879

Score:  0.99

Data Source:  BioPlex,STRINGDB

GRB2

Tchem

Novelty:  0.00091605

p_int:  0.999994907

p_ni:  0.000005093

Score:  0.726

Data Source:  BioPlex,STRINGDB

DNM3

Tbio

Novelty:  0.02365643

p_int:  0.999989332

p_ni:  0.000010668

Score:  0.976

Data Source:  BioPlex,STRINGDB

DNAAF2

Tbio

Novelty:  0.01254416

p_int:  0.982082942

p_ni:  0.017917058

Score:  0.176

Data Source:  BioPlex,STRINGDB

TBC1D15

Tbio

Novelty:  0.11296513

p_int:  0.978167947

p_ni:  0.021832053

Score:  0.344

Data Source:  BioPlex,STRINGDB

NUFIP1

Tbio

Novelty:  0.11726869

p_int:  0.977807543

p_ni:  0.022192457

Data Source:  BioPlex

LYPD6

Tbio

Novelty:  0.13867181

p_int:  0.975163287

p_ni:  0.024836713

Score:  0.41

Data Source:  BioPlex,STRINGDB

DGUOK

Tbio

Family:  Kinase

Novelty:  0.00897987

p_int:  0.951313794

p_ni:  0.048686206

Data Source:  BioPlex

SLC39A9

Tbio

Family:  Transporter

Novelty:  0.06143625

p_int:  0.940399836

p_ni:  0.059600164

Data Source:  BioPlex

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Upstream (1)

1 – 1 of 1

SRC

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  2

1: Endocytosis

2: Bacterial invasion of epithelial cells

Pathways (48)

Reactome (24)

KEGG (5)

PathwayCommons (14)

WikiPathways (5)

Adaptive Immune System (R-HSA-1280218)

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Items per page:

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1 – 5 of 24

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Axon guidance	533 targets	R-HSA-422475
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (49)

Functions (11)

Components (24)

Processes (14)

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1 – 10 of 11

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
GTPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
microtubule binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein kinase binding	Inferred from Sequence or structural Similarity (ISS)	ParkinsonsUK-UCL
D2 dopamine receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
nitric-oxide synthase binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein C-terminus binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	6	4	6		77.5
body height	EFO_0004339	1	1	1		44.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	6		77.5
body height	EFO_0004339	1		44.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Endocytosis
Epilepsy
GTP-binding
Hydrolase

GWAS Trait Find Similar Targets

No Header	No Header
body height
body mass index

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
hearing/vestibular/ear phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dynamin 1	VGNC:4677	107976786
Macaque	dynamin 1		717697
Mouse	dynamin 1	MGI:107384	13429
Rat	dynamin 1	RGD:71096	140694
Dog	dynamin 1	VGNC:51945	491319

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dynamin 1
Macaque	dynamin 1
Mouse	dynamin 1
Rat	dynamin 1
Dog	dynamin 1

Publication Statistics

PubMed Score 307.14

PubMed score by year

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PubTator Score 146.85

PubTator score by year

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Related Publications

Text Mined References (140)

GeneRif Annotations (61)

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PMID	Year	Title