Protein Summary
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000341179
- ENSP00000345680
- ENSG00000106976
- ENST00000372923
- ENSP00000362014
- ENST00000393594
- ENSP00000377219
- ENST00000475805
- ENSP00000419225
- ENST00000486160
- ENSP00000420045
- ENST00000627543
- ENSP00000487310
- DNM
- DNM
- EIEE31
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
protein domain | 1 | ||
molecular function | 0.99 | ||
interacting protein | 0.89 | ||
cellular component | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 307.14 (req: < 5)
Gene RIFs: 61 (req: <= 3)
Antibodies: 609 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 307.14 (req: >= 5)
Gene RIFs: 61 (req: > 3)
Antibodies: 609 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (374)
DNM2
Novelty: 0.00265965
p_int: 0.999999766
p_ni: 2.34e-7
Score: 0.905
Data Source: BioPlex,STRINGDB
SNX9
Novelty: 0.01737783
p_int: 0.999997121
p_ni: 0.000002879
Score: 0.99
Data Source: BioPlex,STRINGDB
GRB2
Novelty: 0.00091605
p_int: 0.999994907
p_ni: 0.000005093
Score: 0.726
Data Source: BioPlex,STRINGDB
DNM3
Novelty: 0.02365643
p_int: 0.999989332
p_ni: 0.000010668
Score: 0.976
Data Source: BioPlex,STRINGDB
DNAAF2
Novelty: 0.01254416
p_int: 0.982082942
p_ni: 0.017917058
Score: 0.176
Data Source: BioPlex,STRINGDB
TBC1D15
Novelty: 0.11296513
p_int: 0.978167947
p_ni: 0.021832053
Score: 0.344
Data Source: BioPlex,STRINGDB
LYPD6
Novelty: 0.13867181
p_int: 0.975163287
p_ni: 0.024836713
Score: 0.41
Data Source: BioPlex,STRINGDB
DGUOK
Family: Kinase
Novelty: 0.00897987
p_int: 0.951313794
p_ni: 0.048686206
Data Source: BioPlex
SLC39A9
Family: Transporter
Novelty: 0.06143625
p_int: 0.940399836
p_ni: 0.059600164
Data Source: BioPlex
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (48)
Reactome (24)
KEGG (5)
PathwayCommons (14)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Axon guidance | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Axon guidance | ||||
Clathrin-mediated endocytosis | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (49)
Functions (11)
Components (24)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | ParkinsonsUK-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body mass index | 6 | 4 | 6 | 77.5 | |||||
body height | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body mass index | 6 | 77.5 | |||||
body height | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dynamin 1 | VGNC:4677 | 107976786 | |||||
Macaque | dynamin 1 | 717697 | ||||||
Mouse | MGI:107384 | 13429 | ||||||
Rat | RGD:71096 | 140694 | ||||||
Dog | dynamin 1 | VGNC:51945 | 491319 | |||||
Publication Statistics
PubMed Score 307.14
PubMed score by year
PubTator Score 146.85
PubTator score by year
Related Publications
Text Mined References (140)
GeneRif Annotations (61)
Items per page:
0 of 0
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