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Tbio
UBE3A
Ubiquitin-protein ligase E3A

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteaso ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232165
  • ENSP00000232165
  • ENSG00000114062
  • ENST00000397954
  • ENSP00000381045
  • ENST00000428984
  • ENSP00000401265
  • ENST00000438097
  • ENSP00000411258
  • ENST00000566215
  • ENSP00000457771
  • ENST00000614096
  • ENSP00000481796
  • ENST00000630424
  • ENSP00000486349
  • ENST00000637886
  • ENSP00000490258
  • ENST00000638011
  • ENSP00000490111
  • ENST00000638155
  • ENSP00000490557
  • ENST00000648336
  • ENSP00000497572
  • ENST00000649550
  • ENSP00000497549
  • ENST00000650110
  • ENSP00000497594

Symbol
  • E6AP
  • EPVE6AP
  • HPVE6A
  • AS
  • ANCR
  • E6-AP
  • HPVE6A
  • EPVE6AP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
viral protein
1
virus
1
transcription factor perturbation
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 802   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 802   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0