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Tbio
UBE3A
Ubiquitin-protein ligase E3A

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteaso ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232165
  • ENSP00000232165
  • ENSG00000114062
  • ENST00000397954
  • ENSP00000381045
  • ENST00000428984
  • ENSP00000401265
  • ENST00000438097
  • ENSP00000411258
  • ENST00000566215
  • ENSP00000457771
  • ENST00000614096
  • ENSP00000481796
  • ENST00000630424
  • ENSP00000486349
  • ENST00000637886
  • ENSP00000490258
  • ENST00000638011
  • ENSP00000490111
  • ENST00000638155
  • ENSP00000490557
  • ENST00000648336
  • ENSP00000497572
  • ENST00000649550
  • ENSP00000497549
  • ENST00000650110
  • ENSP00000497594

Symbol
  • E6AP
  • EPVE6AP
  • HPVE6A
  • AS
  • ANCR
  • E6-AP
  • HPVE6A
  • EPVE6AP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
viral protein
1
virus
1
transcription factor perturbation
0.97


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 705.89   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 705.89   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3A
VGNC:1583
453269
Macaque
ubiquitin protein ligase E3A
711270
Mouse
MGI:105098
22215
Rat
RGD:1306361
361585
Dog
ubiquitin protein ligase E3A
VGNC:48068
479010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3A
Macaque
ubiquitin protein ligase E3A
Mouse
Rat
Dog
ubiquitin protein ligase E3A
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q05086-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (496)
1 – 10 of 496
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.99999997
p_ni: 2.2e-8
p_wrong: 8e-9
Score: 0.377
Data Source: BioPlex,STRINGDB
NSUN2
Tbio
Family: Enzyme
Novelty: 0.01546947
p_int: 0.999999853
p_ni: 1.47e-7
Score: 0.207
Data Source: BioPlex,STRINGDB
PSMD4
Tbio
Family: Enzyme
Novelty: 0.00614538
p_int: 0.999999194
p_ni: 8.06e-7
Score: 0.683
Data Source: BioPlex,STRINGDB
KDELR1
Tbio
Novelty: 0.0036468
p_int: 0.999771813
p_ni: 0.000228187
Score: 0.273
Data Source: BioPlex,STRINGDB
ZNF366
Tbio
Family: TF
Novelty: 0.1166487
p_int: 0.999727739
p_ni: 0.000272261
Data Source: BioPlex
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.999414204
p_ni: 0.000585796
Score: 0.244
Data Source: BioPlex,STRINGDB
TEPSIN
Tdark
Novelty: 0.48775142
p_int: 0.999150597
p_ni: 0.000849403
Data Source: BioPlex
CELA2B
Tdark
Family: Enzyme
Novelty: 0.43122129
p_int: 0.997925516
p_ni: 0.002072321
p_wrong: 0.000002163
Score: 0.181
Data Source: BioPlex,STRINGDB
KLK7
Tchem
Family: Enzyme
Novelty: 0.00757766
p_int: 0.992006487
p_ni: 0.007196823
p_wrong: 0.000796689
Data Source: BioPlex
TRPV5
Tchem
Family: IC
Novelty: 0.0055156
p_int: 0.989367351
p_ni: 0.010621961
p_wrong: 0.000010689
Score: 0.204
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  705.89

PubMed score by year
PubTator Score  390.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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