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Tbio
ICA1
Islet cell autoantigen 1

Protein Summary
Description
May play a role in neurotransmitter secretion. This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265577
  • ENSP00000265577
  • ENSG00000003147
  • ENST00000396675
  • ENSP00000379908
  • ENST00000402384
  • ENSP00000385570
  • ENST00000406470
  • ENSP00000385651
  • ENST00000422063
  • ENSP00000403982

Symbol
  • ICA69
  • ICAp69
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor
0.77
transcription factor perturbation
0.74
virus perturbation
0.72
cellular component
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.18   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.18   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
78.9
monocyte percentage of leukocytes
1
1
1
71.9
neutrophil count
1
1
1
67.9
household income
1
2
2
67.3
mathematical ability
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
78.9
monocyte percentage of leukocytes
1
71.9
neutrophil count
1
67.9
household income
2
67.3
mathematical ability
1
62.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
islet cell autoantigen 1
VGNC:4394
463264
Macaque
islet cell autoantigen 1
695889
Mouse
MGI:96391
15893
Rat
RGD:621465
81024
Dog
islet cell autoantigen 1
VGNC:41854
475242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
islet cell autoantigen 1
Macaque
islet cell autoantigen 1
Mouse
Rat
Dog
islet cell autoantigen 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q05084-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (44)
1 – 10 of 44
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.999999995
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.859
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.999999801
p_ni:  1.95e-7
p_wrong:  4e-9
Data Source:  BioPlex
RAB2A
Tchem
Family:  Enzyme
Novelty:  0.00629151
Score:  0.715
Data Source:  STRINGDB
TPRG1
Tdark
Novelty:  0.53971918
Score:  0.714
Data Source:  STRINGDB
RNF144B
Tbio
Family:  Enzyme
Novelty:  0.02487971
Score:  0.67
Data Source:  STRINGDB
SGSM1
Tbio
Novelty:  0.27948733
Score:  0.645
Data Source:  STRINGDB
FAM124B
Tdark
Novelty:  0.96698909
Score:  0.642
Data Source:  STRINGDB
PKP2
Tbio
Novelty:  0.00493803
Score:  0.636
Data Source:  STRINGDB
PTPRN
Tbio
Family:  Enzyme
Novelty:  0.00076479
Score:  0.623
Data Source:  STRINGDB
ASAP2
Tbio
Novelty:  0.02744569
Score:  0.621
Data Source:  STRINGDB
Publication Statistics
PubMed Score  90.18

PubMed score by year
PubTator Score  122.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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