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Tbio
CSTF1
Cleavage stimulation factor subunit 1

Protein Summary
Description
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217109
  • ENSP00000217109
  • ENSG00000101138

Symbol
  • CstF-50
  • CstFp50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.87
transcription factor binding site profile
0.85
disease perturbation
0.83
tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
80
platelet count
2
2
2
73.8
family history of Alzheimer’s disease
1
2
0
5.9
50.6
2
2
0
5.5
50.6
mean corpuscular hemoglobin concentration
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
80
platelet count
2
73.8
family history of Alzheimer’s disease
0
5.9
50.6
0
5.5
50.6
mean corpuscular hemoglobin concentration
1
39.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cleavage stimulation factor subunit 1
VGNC:9841
100610308
Macaque
cleavage stimulation factor subunit 1
706440
Mouse
MGI:1914587
67337
Rat
RGD:1309267
311670
Dog
cleavage stimulation factor subunit 1
VGNC:39682
612933
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cleavage stimulation factor subunit 1
Macaque
cleavage stimulation factor subunit 1
Mouse
Rat
Dog
cleavage stimulation factor subunit 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q05048-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (269)
1 – 10 of 269
CSTF2T
Tbio
Novelty:  0.11811814
p_int:  0.999999775
p_ni:  1.57e-7
p_wrong:  6.8e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
TOLLIP
Tbio
Novelty:  0.01032371
p_int:  0.999981598
p_ni:  0.000018402
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZBED1
Tbio
Family:  TF
Novelty:  0.01645222
p_int:  0.999441796
p_ni:  0.000558204
Score:  0.163
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999267776
p_ni:  0.000732224
Score:  0.913
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.998902415
p_ni:  0.001097585
Score:  0.909
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.975078681
p_ni:  0.024921318
p_wrong:  1e-9
Data Source:  BioPlex
DLX6
Tbio
Family:  TF
Novelty:  0.01455012
p_int:  0.969368351
p_ni:  0.03063161
p_wrong:  4e-8
Data Source:  BioPlex
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.966582633
p_ni:  0.033417363
p_wrong:  4e-9
Data Source:  BioPlex
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.953201761
p_ni:  0.046798239
Score:  0.245
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.923153306
p_ni:  0.076846692
p_wrong:  2e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  9.17

PubMed score by year
PubTator Score  5.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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